β,β'-Di(phenylsulfonyl)-isobuttersaeure | 36525-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: β,β'-Di(phenylsulfonyl)-isobuttersaeure
• 英文别名: 3-(Benzenesulfonyl)-2-(benzenesulfonylmethyl)propanoic acid
• CAS: 36525-59-4
• 化学式: C₁₆H₁₆O₆S₂
• 分子量: 368.431
• InChiKey: PCWIZOAFPVKXDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG
  申请人：POLYTHERICS LIMITED

  公开号：US10835616B2

  公开（公告）日：2020-11-17

  The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.

  本发明涉及能够与肽或蛋白质中存在的至少一个亲核物反应的新型共轭试剂，该试剂含有至少一个在与所述亲核物反应时失去的离去基团，其中离去基团包括-(CH2CH2O)n-部分，其中n为6或6以上的数字；以及使用此类试剂制备含有肽或蛋白质的共轭物的新型工艺。
• PROCESS FOR THE CONJUGATION OF A PEPTIDE OR PROTEIN WITH A REAGENT COMPRISING A LEAVING GROUP INCLUDING A PORTION OF PEG
  申请人：Polytherics Limited

  公开号：EP3218009B1

  公开（公告）日：2021-04-07
• Process For The Conjugation Of A Peptide Or Protein With A Reagent Comprising A Leaving Group Including A Portion Of PEG
  申请人：POLYTHERICS LIMITED

  公开号：US20170304461A1

  公开（公告）日：2017-10-26

  The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH 2 CH 2 O) n —, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
• [EN] PROCESS FOR THE CONJUGATION OF A PEPTIDE OR PROTEIN WITH A REAGENT COMPRISING A LEAVING GROUP INCLUDING A PORTION OF PEG<br/>[FR] PROCÉDÉ POUR LA CONJUGAISON D'UN PEPTIDE OU D'UNE PROTÉINE AVEC UN RÉACTIF COMPRENANT UN GROUPE PARTANT COMPORTANT UNE PARTIE DE PEG
  申请人：POLYTHERICS LTD

  公开号：WO2016059377A1

  公开（公告）日：2016-04-21

  The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion -(CH2CH2O)n- in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.