1-Methyl-2-phenylethanesulfonamide | 76653-19-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methyl-2-phenylethanesulfonamide
• 英文别名: 1-phenyl-2-propanesulfonamide；1-phenylpropane-2-sulfonamide；(±)-1-phenylpropane-2-sulfonamide
• CAS: 76653-19-5
• 化学式: C₉H₁₃NO₂S
• 分子量: 199.274
• InChiKey: UGINXJBANWOKBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 乙醇 为溶剂， 以95%的产率得到1-Methyl-2-phenylethanesulfonamide
  参考文献：
  名称：

  A new synthesis of α-functionalized unsubstituted sulfonamides

  摘要：

  DOI：

  10.1016/s0040-4039(00)88845-0

文献信息

• [EN] PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN<br/>[FR] DÉRIVÉS DE PIPÉRAZINE AYANT UNE ACTIVITÉ MULTIMODE CONTRE LA DOULEUR
  申请人：ESTEVE LABOR DR

  公开号：WO2015092009A1

  公开（公告）日：2015-06-25

  The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有对σ受体和μ-阿片受体双重药理活性的化合物，更特别地涉及具有这种药理活性的哌嗪化合物，以及制备这种化合物的方法，包括含有它们的药物组合物，以及它们在治疗中的应用，特别是用于疼痛治疗。
• FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0714897A1

  公开（公告）日：1996-06-05

  A cyclopentene derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof: wherein Ar¹ and Ar² represent each independently phenyl, thienyl, pyridyl, indolyl, benzofuranyl or dihydrobenzofuranyl; A represents a group that is combined with the adjacent carbon-carbon double bond to form a 5-or 6-membered heteroaromatic ring containing one to four heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and Y represents -CO-R⁴, SO₃H, PO₃H₂, tetrazol-5-yl, 2-oxo-3H-1,2,3,5-oxathiadiazol-4-yl or 5-oxo-4H-1,2,4-oxadiazol-3-yl.

  通式 (I) 所代表的环戊烯衍生物及其药学上可接受的盐：其中 Ar¹ 和 Ar² 各自独立地代表苯基、噻吩基、吡啶基、吲哚基、苯并呋喃基或二氢苯并呋喃基；A 代表一个基团，该基团与相邻的碳碳双键结合形成一个 5 或 6 元杂芳环，该环含有一至四个杂原子，这些杂原子选自由氮、氧和硫组成的组；Y 代表-CO-R⁴、SO₃H、PO₃H₂、四唑-5-基、2-氧代-3H-1,2,3,5-噁二唑-4-基或 5-氧代-4H-1,2,4-噁二唑-3-基。
• Asymmetric synthesis of .alpha.-functionalized primary sulfonamides
  作者：Franklin A. Davis、Ping Zhou、Patrick J. Carroll

  DOI：10.1021/jo00070a026

  日期：1993.8

  Alpha-Functionalized primary sulfonamides 8 are prepared in good to excellent yields by treatment of the dianions of N-sulfonylcamphorimines 1-3 with electrophiles and hydrolysis of the resulting imines 5-7. Alkylation of the anions of N-sulfonyl-10-camphorsulfonamide imines 2 and 3 with primary and secondary alkyl iodides and with ethylene oxide, following removal of the chiral auxiliary with aqueous acid, gave primary sulfonamides with ee's in the range of 66-95%.
• The decomposition of .beta.-phenethylsulfonyl azides. Solution chemistry and flash vacuum pyrolysis
  作者：Rudolph A. Abramovitch、William D. Holcomb、Shigeo Wake

  DOI：10.1021/ja00396a039

  日期：1981.3
• ENDOTHELIN ANTAGONISTS FOR TREATING HEART FAILURE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0906108B1

  公开（公告）日：2005-06-15