2-phenyl-2-(7(9)H-purin-6-ylamino)-ethanol | 19254-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-phenyl-2-(7(9)H-purin-6-ylamino)-ethanol
• 英文别名: Benzeneethanol, I(2)-(1H-purin-6-ylamino)-, (S)-；(2S)-2-phenyl-2-(7H-purin-6-ylamino)ethanol
• CAS: 19254-72-9
• 化学式: C₁₃H₁₃N₅O
• 分子量: 255.279
• InChiKey: HVLWZOSYRXDKLY-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  86.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE<br/>[FR] COMPOSITIONS ET LEURS MÉTHODE D'UTILISATION POUR LE TRAITEMENT D'UNE MALADIE NEURODEGENERATIVE ET MITOCHONDRIALE
  申请人：MITOKININ INC

  公开号：WO2020206363A1

  公开（公告）日：2020-10-08

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及含氮杂环类似物，制备含氮类似物的方法，以及使用这些类似物治疗与PINK1激酶活性相关的疾病的方法，包括但不限于神经退行性疾病、线粒体疾病、纤维化和/或心肌病。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• Purine derivatives, process for their preparation and use thereof
  申请人：——

  公开号：US20030187261A1

  公开（公告）日：2003-10-02

  The present invention relates to new purine derivatives and their deaza- and aza-analogues, methods for preparing said derivatives, and to their use in suitable utilities, in particular their use in diagnostics and therapeutic methods. The invention relates in particular to purine derivatives with an inhibitory effect on for example cyclin-dependent kinase proteins (sdks), viruses, and proliferation of haemotapoietic and cancer cells.

  本发明涉及新的嘌呤衍生物及其去氮和氮杂类似物，制备这些衍生物的方法，以及它们在适当的实用程序中的使用，特别是它们在诊断和治疗方法中的使用。本发明特别涉及具有抑制作用的嘌呤衍生物，例如对于细胞周期依赖性激酶蛋白（sdks）、病毒和造血和癌细胞增殖等。
• BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS
  申请人：PHARMACIA & UPJOHN S.p.A.

  公开号：EP0853616B1

  公开（公告）日：2001-09-19
• PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF
  申请人：UNIVERSITAIRE INSTELLING ANTWERPEN

  公开号：EP1244668B1

  公开（公告）日：2006-04-05
• COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
  申请人：MITOKININ, INC.

  公开号：US20220162215A1

  公开（公告）日：2022-05-26

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.