N-hydroxy-1,3-benzodioxole-4-carboxamide | 1198321-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: N-hydroxy-1,3-benzodioxole-4-carboxamide
• CAS: 1198321-42-4
• 化学式: C₈H₇NO₄
• mdl: MFCD17170767
• 分子量: 181.15
• InChiKey: HWJYJRHEEBDKQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS<br/>[FR] COMPOSES D'ACIDE HYDROXAMIQUE, SULFONYLARYLE OU HETEROARYLE
  申请人：PHARMACIA CORP

  公开号：WO2001085680A2

  公开（公告）日：2001-11-15

  A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity. A contemplated compound corresponds in structure to the formula (I) wherein W and the R groups are defined elsewhere.