m-nitrobenzoyloxyacetaldehyde dibenzyl acetal | 547752-83-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: m-nitrobenzoyloxyacetaldehyde dibenzyl acetal
• 英文别名: 2,2-Bis(phenylmethoxy)ethyl 3-nitrobenzoate
• CAS: 547752-83-0
• 化学式: C₂₃H₂₁NO₆
• 分子量: 407.423
• InChiKey: RCCIWPFGASEQAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES<br/>[FR] INHIBITEURS DE METALLOPROTEASES MATRICES A BASE D'HYDROXAMATES CYCLIQUES SUBSTITUES
  申请人：INCYTE CORP

  公开号：WO2005037826A1

  公开（公告）日：2005-04-28

  The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.

  本发明提供了公式I的化合物：其对映异构体，二对映异构体，混合物，前药，结晶形式，非晶形式，无定形形式，溶剂化物，代谢物和药学上可接受的盐，其中环A取代基在以下披露中被完全定义。公式I的化合物是金属蛋白酶抑制剂，如基质金属蛋白酶和剪切酶的抑制剂，并且在治疗风湿性关节炎，牛皮癣，肿瘤性疾病，过敏和所有需要MMPs抑制的疾病中有用。
• Preparation of intermediates useful in the synthesis of antiviral nucleosides
  申请人：——

  公开号：US20030162992A1

  公开（公告）日：2003-08-28

  The present invention is an efficient process for the manufacture of &agr;-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

  本发明是一种制备&agr;-酰氧基乙醛的高效过程，该化合物是合成1,3-噻二环己烷和1,3-二氧杂环己烷核苷的关键中间体。
• EP1461041A4
  申请人：——

  公开号：EP1461041A4

  公开（公告）日：2006-03-29
• PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANTIVIRAL NUCLEOSIDES
  申请人：Pharmasset Ltd.

  公开号：EP1461041A2

  公开（公告）日：2004-09-29
• SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES
  申请人：INCYTE CORPORATION

  公开号：EP1678167A1

  公开（公告）日：2006-07-12