Methyl 3-(3-phenoxyphenyl)prop-2-enoate | 87087-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-(3-phenoxyphenyl)prop-2-enoate
• CAS: 87087-33-0
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.28
• InChiKey: GPKUSCCWJPPDPE-UHFFFAOYSA-N

物化性质

• 沸点：
  381.9±25.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS
  申请人：Universiteit Leiden

  公开号：EP3095787A1

  公开（公告）日：2016-11-23

  The present invention relates to novel compounds which are highly selective inhibitors of diacylglycerol lipase α and β. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by increased 2-arachidonoylglycerol levels. Diacylglycerol lipase-α (alternative name: Sn1-specific diacylglycerol hydrolase a; DAGL-α) and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The inventive ompounds are in particular suitable for the treatment of neurodegenerative diseases, inflammatory diseases, drug abuse and impaired energy balance, such as obesity.

  这项发明涉及一种新型化合物，它们是高选择性的二酰甘油脂酶α和β的抑制剂。这些化合物适用于治疗或预防与增加2-花生四烯酰基甘油水平相关、伴随或由此引起的疾病。二酰甘油脂酶-α（另一名称：Sn1特异性二酰甘油水解酶a；DAGL-α）和-β是负责内源大麻素2-花生四烯酰基甘油的生物合成的酶。需要选择性和可逆的抑制剂来研究神经细胞中DAGLs的功能，以一种急性和暂时的方式。这些创新的化合物特别适用于治疗神经退行性疾病、炎症性疾病、药物滥用和受损的能量平衡，如肥胖症。
• Anti-epileptogenic agents
  申请人：Queen's University at Kingston and Neurochem, Inc.

  公开号：US20030194375A1

  公开（公告）日：2003-10-16

  Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and/or epileptogenesis. Methods for preparing the compounds of the invention are also described.

  本发明揭示了用于抑制惊厥性疾病，包括癫痫的方法和化合物。本发明的方法和化合物抑制或预防了发作和/或癫痫发作。还描述了制备本发明化合物的方法。
• Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0363782A1

  公开（公告）日：1990-04-18

  Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula wherein each of A and B is a group of formula (i) to (iii): wherein Y is -O-, -S- or -NR- in which R is hydrogen or C₁-C₆ alkyl; each of R₃, R₄, R₅ and R₆ is independently: a) hydrogen, halogen, hydroxy, cyano or nitro; b) C₁-C₆ alkyl unsubstituted or substituted by halogen, c) C₁-C₆ alkoxy or C₁-C₆ alkylthio; d) C₁-C₆ alkyl-sulfonyl; e) a substituted amine group -NR₇R₈; f) a -COR₁₂ group; or g) two adjacent groups of R₃, R₄, R₅ and R₆, taken together, form a C₁-C₄ alkylenedioxy group; each of R₁ and R₂ independently is hydrogen, C₃-C₆ alkynyl, C₃-C₆ alkenyl or C₁-C₆ alkyl unsubstituted or substituted by phenyl; or R₁ and R₂ taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepresssant, antiobesity antismoking and anti-alcoholabuse agents.

  式胺的芳氧基和杂芳氧基烯烃衍生物 其中A和B各自为式(i)至(iii)的基团： 其中 Y 为-O-、-S-或-NR-，其中 R 为氢或 C₁-C₆ 烷基；R₃、R₄、R₅ 和 R₆ 各自独立： a) 氢、卤素、羟基、氰基或硝基； b) 未被卤素取代或取代的 C₁-C₆ 烷基、 c) C₁-C₆ 烷氧基或 C₁-C₆ 烷硫基； d) C₁-C₆烷基磺酰基； e) 取代的胺基团-NR₇R₈； f) 一个-COR₁₂基团；或 g) 两个相邻的 R₃、R₄、R₅ 和 R₆ 基团共同形成 C₁-C₄ 烷二氧基； R₁和R₂各自独立地为氢、C₃-C₆炔基、C₃-C₆烯基或未取代或被苯基取代的C₁-C₆烷基；或 R₁和R₂与它们相连的氮原子一起形成一个取代或未取代的饱和杂环；及其药学上可接受的盐；对中枢神经系统具有活性，特别是作为抗抑郁剂、抗肥胖剂、抗吸烟剂和抗酒精滥用剂。
• Chemical intermediates
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0390228A2

  公开（公告）日：1990-10-03

  intermediates of formula:- wherein Q is selected from carbon bearing a hydrogen atom and nitrogen; Z represents one or more substituents selected from fluoro, benzyl, phenoxy, chlorophenoxy, fluorophenoxy and bromophenoxy, and R4 is selected from hydroxy, bromo, chloro and iodo, or R4 is selected from a group of formula:-- P(R)3 and a group of formula:- wherein R represents alkyl or aryl. The intermediates of the invention are useful in the preparation of insecticidal compoumds.

  式的中间体 其中 Q 选自含氢原子的碳和氮；Z 代表一个或多个取代基，选自氟、苄基、苯氧基、氯苯氧基、氟苯氧基和溴苯氧基，R4 选自羟基、溴基、氯基和碘基，或 R4 选自式基团：- P(R)3 和一个式组 其中 R 代表烷基或芳基。本发明的中间体可用于制备杀虫化合物。
• Diphenyl ether derivatives
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0240121B1

  公开（公告）日：1991-04-17