thioflavin T | 20096-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: thioflavin T
• 英文别名: 2-[4-(Dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium；4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline
• CAS: 20096-11-1
• 化学式: C₁₇H₁₉N₂S
• 分子量: 283.417
• InChiKey: FXEKRIDRIFBJOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cucurbit[14]uril 、 thioflavin T 以 水 为溶剂， 生成
  参考文献：
  名称：

  碱性土阳离子介导的硫代黄素T与葫芦丝的光致发光配合物[14]尿

  摘要：

  我们第一次报道了碱土金属离子介导的硫代黄素T（ThT）与扭曲葫芦[14] uril（tQ [14]）的固体光致发光配合物。与tQ [14]的相互作用增强了水溶液中ThT的荧光。实际上，随着tQ [14]的增加，ThT的荧光强度迅速增加，直到tQ [14]：ThT的比率为15。有趣的是，在更低的tQ [14]：ThT的比率（1：1）下，引入了碱土金属阳离子（AE 2+）进入tQ [14] -ThT相互作用系统导致ThT的荧光猝灭，Mg 2+除外阳离子，导致最初的荧光增强，然后ThT逐渐荧光猝灭。在较高的tQ [14]：ThT比（1:15）下，将碱土金属阳离子引入tQ [14] -ThT相互作用系统导致固体tQ [14] / ThT / AE 2+相互作用产物沉淀，它发出强烈的蓝色荧光，但Sr 2+阳离子除外，它显示ThT的荧光猝灭而没有任何固体沉淀。因此，TQ [14] -ThT交互系统显示

  DOI：

  10.1039/c7nj04115b

文献信息

• 2-ARYLBENZOTHIOPHENE DERIVATIVES OR PHARCEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARCEUTICAL COMPOSITION FOR THE DIAGNOSIS OR TREATMENT OF DEGENERATIVE BRAIN DISEASE CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：Chi Dae Yoon

  公开号：US20100261727A1

  公开（公告）日：2010-10-14

  2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for β-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R 1 -R 4 , V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight β-amyloid peptide binding compound, generation of malignant high-molecular weight β-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.

  2-芳基苯并噻吩衍生物或其药用可接受盐，其制备方法，以及包含其作为活性成分的用于诊断或治疗退行性脑疾病的药物组合物。由于式1中的2-芳基苯并噻吩衍生物具有相对较高的β-淀粉样蛋白结合亲和力，因此当它们与放射性同位素标记时，它们可以作为诊断试剂用于通过非侵入性技术早期诊断阿尔茨海默病： 其中R1-R4，V，W，X，Y和Z如规范的详细描述中所定义。此外，当含有2-芳基苯并噻吩衍生物的药物组合物与低分子量β-淀粉样蛋白结合化合物结合时，最小化了恶性高分子量β-淀粉样蛋白沉积物的生成。因此，该药物组合物可用作治疗阿尔茨海默病等退行性脑疾病的治疗剂。
• Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques
  申请人：Jeong Jae Min

  公开号：US20070122341A1

  公开（公告）日：2007-05-31

  Benzylideneaniline derivatives of formula 1 wherein R1-R5 are independently selected from hydrogen, C 1 -C 4 alkyl and F (at least one of them is F) and each R 6 -R 10 are independently selected from hydrogen, C 1 -C 4 alkyl, OH, OCH 3 , NH 2 , NHCH 3 and N(CH 3 ) 2 (at least one of them is OH, OCH 3 , NH 2 , NHCH 3 or N(CH 3 ) 2 ) are disclosed. Benzylideneaniline derivatives according to the present invention have high affinity to β-amyloid plaques. Thus, they can cross the blood-brain-barrier (BBB) and bind to β-amyloid plaques after administration into the body, making them useful for treatment, prevention, or imaging of Alzheimer's disease.

  公开了公式1的苯甲醛苯胺衍生物，其中R1-R5分别选自氢、C1-C4烷基和F（它们中至少有一个是F），每个R6-R10分别选自氢、C1-C4烷基、OH、O 、NH2、NH 和N(CH3)2（它们中至少有一个是OH、O 、NH2、NH 或N( )2）。根据本发明的苯甲醛苯胺衍生物具有高亲和力β-淀粉样斑块。因此，它们可以穿过血脑屏障（BBB），在体内给药后结合β-淀粉样斑块，使其用于治疗、预防或成像阿尔茨海默病。
• Basic Yellow Dyes as Dye Component for Optical Data Recording Media
  申请人：Steffanut Pascal

  公开号：US20090018318A1

  公开（公告）日：2009-01-15

  The present invention relates to the use of Basic Yellow dyes as dye component for optical data recording media. In a preferred aspect the present invention relates to Basic Yellow dyes together with a metalazo complex dye as dye components for optical data recording media. In a more preferred aspect, the invention relates to a write once read many (WORM) type optical data recording medium capable of recording and reproducing information with radiation of blue laser of preferably 405 nm, which employs a Basic Yellow dye together with a metalazo complex dye and a further recording dye in the optical layer.

  本发明涉及将基本黄染料用作光学数据记录介质的染料组分。在一个首选方面，本发明涉及基本黄染料与金属偶氮络合染料作为光学数据记录介质的染料组分。在更首选的方面，该发明涉及一种一次性写入多次读取（WORM）类型的光学数据记录介质，能够使用蓝光激光（最好为405纳米）记录和再现信息，该介质在光学层中使用基本黄染料与金属偶氮络合染料以及另一种记录染料。
• 3-hydroxy-cyclohex-2-enone based azo dyes, and their use with anionic azo metal complex dyes
  申请人：Clariant International Ltd.

  公开号：EP1925642A1

  公开（公告）日：2008-05-28

  The present invention relates to the use of 3-hydroxy-cyclohex-2-enone azo based dyes and/or of azo metal complex dyes made thereof, and to compositions comprising 3-hydroxy-cyclohex-2-enone azo based dyes and anionic azo metal complex dyes with cationic basic yellow dyes in optical layers for optical data recording, preferably for optical data recording using a laser with a wavelength up to 450 nm. The invention further relates to a write once read many (WORM) type optical data recording medium capable of recording and reproducing information with radiation of blue laser, which employs a 3-hydroxy-cyclohex-2-enone azo based dye and/or an azo metal complex dye made thereof, or a composition comprising a 3-hydroxy-cyclohex-2-enone azo based dye and a anionic azo metal complex dye with a cationic basic yellow dye in the optical layer.

  本发明涉及使用3-羟基环己-2-烯酮偶氮基染料和/或由此制成的偶氮金属络合物染料，以及包含3-羟基环己-2-烯酮偶氮基染料和带有阳离子基本黄染料的阴离子偶氮金属络合物染料的组合物，在光学层中用于光学数据记录，最好用于使用波长高达450纳米的激光进行光学数据记录。该发明还涉及一种一次写多次读（WORM）型光学数据记录介质，能够使用蓝激光记录和复制信息，该介质采用3-羟基环己-2-烯酮偶氮基染料和/或由此制成的偶氮金属络合物染料，或者包含3-羟基环己-2-烯酮偶氮基染料和光学层中的带有阳离子基本黄染料的阴离子偶氮金属络合物染料的组合物。
• (3-FLUORO-2-HYDROXY)PROPYL-FUNCTIONALIZED ARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR THE DIAGNOSIS OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASES
  申请人：Chi Dae-Yoon

  公开号：US20120214994A1

  公开（公告）日：2012-08-23

  The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to β-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease. Further, the aryl derivatives of the present invention bind to low molecular β-amyloid peptide conjugates to inhibit the generation of malignant high molecular β-amyloid plaque, and thus can be effectively used as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer's disease.

  本发明涉及（3-氟-2-羟基）丙基官能化芳基衍生物或其药用可接受的盐，以及制备该衍生物的方法，以及含有该衍生物作为活性成分的药物组合物，用于诊断或治疗神经退行性脑疾病。本发明的芳基衍生物经（3-氟-2-羟基）丙基官能化以增加其极性，因此含有该芳基衍生物的药物可以轻松渗透到脑血管膜中，从而增加药物的有效性。由于本发明的芳基衍生物与β-淀粉样蛋白结合强，因此当该芳基衍生物标记放射性同位素时，可用作无创诊断早期阿尔茨海默病的诊断剂。此外，本发明的芳基衍生物与低分子量β-淀粉样肽结合以抑制恶性高分子量β-淀粉样斑块的生成，因此可以有效用作治疗阿尔茨海默病等神经退行性脑疾病的治疗剂。