2,5-Di-tert-butyl-3-methylbenzene-1,4-diol | 71745-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Di-tert-butyl-3-methylbenzene-1,4-diol
• 英文别名: 2,5-ditert-butyl-3-methylbenzene-1,4-diol
• CAS: 71745-72-7
• 化学式: C₁₅H₂₄O₂
• 分子量: 236.35
• InChiKey: FZNYTOPOPKVJNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• US4219570A
  申请人：——

  公开号：US4219570A

  公开（公告）日：1980-08-26
• [EN] NOVEL METHODS<br/>[FR] NOUVEAUX PROCÉDÉS
  申请人：MONELL CHEMICAL SENSES CENTRE

  公开号：WO2012168474A1

  公开（公告）日：2012-12-13

  The invention provides methods for screening for compounds that modulate SERCA3 activity, and, in turn, regulate the production of GLP-1, as well as methods of treatment or prophylaxis of metabolic diseases, obesity, diseases and disorders involving abnormal intestinal motility, and other diseases and disorders mediated by GLP-1, and compositions comprising SERCA3 inhibitors. The invention also provides a Serca3 modulator for use as a medicament, a Serca3 modulator for use in the treatment of the aforementioned disease states and, the use of a Serca3 modulator in the manufacture of a medicament for the treatment of the aforementioned disease states.