[Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂] | 1581274-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂]
• CAS: 1581274-10-3
• 化学式: C₃₂H₃₆F₄Pt₂S₂
• 分子量: 950.923
• InChiKey: HZEGFZSJOQYJMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  N,N-Dimethyl-N'-(p-chlorbenzyliden)ethylendiamin 、 [Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂] 以 甲苯 为溶剂， 反应 4.0h， 以86.4%的产率得到
  参考文献：
  名称：

  Exploring the Scope of [Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂] as a Precursor for New Organometallic Platinum(II) and Platinum(IV) Antitumor Agents

  摘要：

  The new compound [Pt-2(4-FC6H4)(4)(mu-SEt2)(2)] (A) was prepared and fully characterized. The reactions of compound A with ligands ArCH=NCH2CH2NMe2 (Ar = 2-BrC6H4, 1a; 2,6-Cl2C6H3, 1b; 4-ClC6H4, 1c; 2-Cl,6-FC6H3, 1d) were studied under different conditions and produced platinum(II) compounds [Pt(4-FC6H4)2(ArCH=NCH2CH2NMe2)] (2b-2d), containing a bidentate [N,N'] ligand, as well as cyclometalated platinum(IV) or platinum(II) compounds such as [PtBr(4-FC6H4)(2)(C6H4CH=NCH2CH2NMe2)] (4a) or [PtCl{(3-FC6H3)(2-XC6H3)CH=NCH2CH2NMe2)] (5b: X = Cl; 5d: X = F), containing a tridentate [C,N,N'] ligand and either a five (4a) or a seven (5b, 5d) membered metallacycle. These compounds exhibit a great antiproliferative activity against non-small lung cancer cells (A549), and the best result was obtained for compound 2c (IC50 = 0.3 +/- 0.1 mu M). While compounds 5 alter the mobility of plasmid DNA in a similar way to cisplatin, compound 4 was less efficient in removing the supercoils from DNA. In spite of the very low IC50 value obtained for compound 2c, this compound does not interact with DNA, and it is neither an intercalator nor a topoisomerase 1 inhibitor.

  DOI：

  10.1021/om5000908
• 作为产物：
  描述：

  bis-μ-diethylthio-bis[dichloroplatinum(II)] 、 对氟碘苯 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 2.5h， 以53.8%的产率得到[Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂]
  参考文献：
  名称：

  Exploring the Scope of [Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂] as a Precursor for New Organometallic Platinum(II) and Platinum(IV) Antitumor Agents

  摘要：

  The new compound [Pt-2(4-FC6H4)(4)(mu-SEt2)(2)] (A) was prepared and fully characterized. The reactions of compound A with ligands ArCH=NCH2CH2NMe2 (Ar = 2-BrC6H4, 1a; 2,6-Cl2C6H3, 1b; 4-ClC6H4, 1c; 2-Cl,6-FC6H3, 1d) were studied under different conditions and produced platinum(II) compounds [Pt(4-FC6H4)2(ArCH=NCH2CH2NMe2)] (2b-2d), containing a bidentate [N,N'] ligand, as well as cyclometalated platinum(IV) or platinum(II) compounds such as [PtBr(4-FC6H4)(2)(C6H4CH=NCH2CH2NMe2)] (4a) or [PtCl{(3-FC6H3)(2-XC6H3)CH=NCH2CH2NMe2)] (5b: X = Cl; 5d: X = F), containing a tridentate [C,N,N'] ligand and either a five (4a) or a seven (5b, 5d) membered metallacycle. These compounds exhibit a great antiproliferative activity against non-small lung cancer cells (A549), and the best result was obtained for compound 2c (IC50 = 0.3 +/- 0.1 mu M). While compounds 5 alter the mobility of plasmid DNA in a similar way to cisplatin, compound 4 was less efficient in removing the supercoils from DNA. In spite of the very low IC50 value obtained for compound 2c, this compound does not interact with DNA, and it is neither an intercalator nor a topoisomerase 1 inhibitor.

  DOI：

  10.1021/om5000908

文献信息

• Kinetico-mechanistic studies on the formation of seven-membered [C,N]-platinacycles: the effect of methyl or fluoro substituents on the aryl ancillary ligands
  作者：Margarita Crespo、Mercè Font-Bardia、Manuel Martínez

  DOI：10.1039/c5dt01926e

  日期：——

  The rate determining step for the formation of seven-membered platinacycles from cyclometallated Pt(iv) aryl complexes is determined by the nature of the substituents on the aryl groups.

  形成七元铂环化合物的速率决定步骤取决于芳基配合物中芳基基团的取代基性质。