Rh2(O2CCH3)4(4-CH3C5H4N)2 | 55960-37-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Rh2(O2CCH3)4(4-CH3C5H4N)2
• CAS: 55960-37-7
• 化学式: C₂₀H₂₆N₂O₈Rh₂
• 分子量: 628.246
• InChiKey: GJUAXHLDEDFFHI-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  4-甲基吡啶 、 dirhodium tetraacetate 以 乙醇 、 水 为溶剂， 反应 168.0h， 以93%的产率得到Rh2(O2CCH3)4(4-CH3C5H4N)2
  参考文献：
  名称：

  Synthesis, crystal structures and catalytic activity of tetrakis(acetato)dirhodium(II) complexes with axial picoline ligands

  摘要：

  Three complexes were synthesized in high yields by reaction of Rh-2(O2CCH3)(4) with 2-picoline (1), 3-picoline (2) and 4-picoline (3), respectively, and characterized by elemental analysis, ESI+-MS, FT-IR and H-1 NMR along with single-crystal X-ray structural analysis. All picoline ligands coordinate to the axial sites of Rh-2(O2CCH3)(4) via the pyridine nitrogen atoms, and interestingly, the coordination of 2-picoline in 1 is assisted by two intramolecular C-H center dot center dot center dot O hydrogen bonds formed between the methyl of 2-picoline and the oxygen atoms of Rh2(O2CCH3)(4). Moreover, the intermolecular C-H center dot center dot center dot O interactions play the main role in the structural stacking of 1-3. Their catalytic activity was evaluated in the C-H insertion reactions for the preparation of 4-nitrobenzyl-(4R, 5R, 6S)-6-((R)-1-hydroxyethyl)-4-methyl-3,7-dioxo-1-azabicyclo [3.2.0] heptane-2-carboxylate, a key intermediate of Meropenem. The isolated yields for 1, 2 and 3 are 44%, 16% and 22%, respectively, significantly lower than the value of Rh2(O2CCH3) 4 (73%), indicating that the axial ligands have negative but different influence on the catalytic activity. The activities of 1-3 are related to the displacement rate of the axial ligands, and essentially related to the Rh-N bond lengths which strong affect the displacement rate. Therefore, it is possible to tune the catalytic activity of Rh-2(O2CCH3)(4) by changing its axial ligands. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2015.05.017

文献信息

• Mal'kova, T. A.; Shafranskii, V. N., Zhurnal Obshchei Khimii, 1975, vol. 45, p. 618 - 621
  作者：Mal'kova, T. A.、Shafranskii, V. N.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Rh: SVol.B2, 1.1.2.2.1.7, page 22 - 23
  作者：

  DOI：——

  日期：——