4,4-diphenyl-2-isopropenyl-2-oxazolin-5-one | 119221-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4-diphenyl-2-isopropenyl-2-oxazolin-5-one
• 英文别名: 2-isopropenyl-4,4-diphenyl-1,3-oxazolin-5-one；4,4-Diphenyl-2-prop-1-en-2-yl-1,3-oxazol-5-one
• CAS: 119221-35-1
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: HIPFXTMAGCIYHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• AZETIDINIUM-CONTAINING COPOLYMERS AND USES THEREOF
  申请人：Novartis AG

  公开号：US20160326395A1

  公开（公告）日：2016-11-10

  The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

  这项发明涉及含有氮杂环丙铵的共聚物和乙烯基单体，以及它们在硅水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。
• PREPOLYMERS SUITABLE FOR MAKING ULTRA-VIOLET ABSORBING CONTACT LENSES
  申请人：Domschke Angelika Maria

  公开号：US20110063567A1

  公开（公告）日：2011-03-17

  The invention provides a class of actinically-crosslinkable silicone-containing prepolymers which comprise (1) ethylenically-unsaturated groups and (2) UV-absorbing polymeric units, latent UV-absorbing polymeric units, and/or dual photo-functional polymeric units. The prepolymer of the invention can be used to prepare silicone hydrogel contact lenses capable of absorbing UV/visible radiation. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.

  本发明提供一类光致交联硅含量预聚物，其包括（1）乙烯基-不饱和基团和（2）紫外线吸收聚合物单元、潜在紫外线吸收聚合物单元和/或双重光功能聚合物单元。本发明的预聚物可用于制备能够吸收紫外线/可见光辐射的硅水凝胶隐形眼镜。本发明还涉及使用本发明预聚物制造硅水凝胶隐形眼镜的方法，以成本效益高、一致性高和对原始镜片设计的高度忠实。
• Continuous process for making polymers having pendant azlactone or macromolecular moieties
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0160397A2

  公开（公告）日：1985-11-06

  A bulk polymerization process for free radical polymerization of vinyl monomers and alkenyl azlactones or macromolecular monomers (e.g. functionalized polystyrene), in a wiped surface reactor is disclosed. Referring to Figure 1; monomer streams (5) (after purification and silica get column 2), and (7) and macromer or azlactone (8) are combined with free radical initiator (9) to form a premix (16). Pump (18) transfers the premix stream (22) through static mixer (24) into a wiped surface reactor (27). The reactor can be a counter rotating twin screw extruder which produces polymer stream (36) without the need of solvent and using residence times much shorter than prior art solution or emulsion processes. Some unique pressure sensitive adhesive acrylate polymers have been produced. They are believed to have a relatively high degree of branching. The bulk polymerization process permits the manufacture of pressure sensitive adhesive articles by extruding directly from the twin screw extruder onto a substrate.

  本发明公开了一种用于乙烯基单体和烯丙基叠氮内酯或大分子单体（如官能化聚苯乙烯）在抹面反应器中进行自由基聚合的批量聚合工艺。参见图 1；单体流（5）（经过净化和硅胶得到柱 2）、（7）和大分子单体或氮内酯（8）与自由基引发剂（9）结合形成预混料（16）。泵（18）将预混料流（22）通过静态混合器（24）输送到擦拭表面反应器（27）中。反应器可以是一个反向旋转的双螺杆挤出机，它生产聚合物流（36）时不需要溶剂，停留时间也比现有技术的溶液或乳液工艺短得多。 现已生产出一些独特的压敏型丙烯酸酯粘合剂聚合物。据信，它们的分支程度相对较高。散装聚合工艺可将压敏胶直接从双螺杆挤出机挤出到基材上，生产压敏胶制品。
• Azlactone graft copolymers
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0392783A2

  公开（公告）日：1990-10-17

  Graft copolymers and processes for the preparation thereof are provided. The copolymers comprise a base polymer having grafted thereto a monomeric 2-alkenyl azlactone. The surface properties of the graft copolymers can be modified by binding thereto nucleophilic reagents comprising further functional groups with desired properties. Further, the amount of azlactone available at the surface of a graft copolymer for binding to such nucleophilic reagents can be controlled by selecting a surface against which the graft copolymer is formed. The graft copolymers exhibit desirable thermoplastic, melt flow, and adhesion properties and are particularly useful for immobilizing proteins. Methods of immunoassay based on the immobilization of proteins are also disclosed. Another utility of the graft copolymers involves the compatibilizing of immiscible polymer blends.

  提供了接枝共聚物及其制备工艺。这种共聚物包括一种接枝了 2-烯基氮内酯单体的基础聚合物。接枝共聚物的表面性质可通过与亲核试剂结合而改变，亲核试剂包括具有所需性质的其他官能团。此外，接枝共聚物表面可用于与此类亲核试剂结合的氮内酯量可通过选择形成接枝共聚物的表面来控制。接枝共聚物具有理想的热塑性、熔融流动性和粘附性，特别适用于固定蛋白质。此外，还公开了基于固定蛋白质的免疫测定方法。接枝共聚物的另一个用途是使不相溶的聚合物混合物相容。
• Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0784063A2

  公开（公告）日：1997-07-16

  An azalactone-functional thermoplastic composition is disclosed. The composition is a blend of an azalactone-functional composition and a thermoplastic polymer. A method of making azalactone-functional homopolymers by bulk homopolymerization is disclosed, optionally also concurrent or sequential blending of a thermoplastic polymer. A method of blending azalactone-functional compositions and thermoplastic polymers is disclosed. Molded articles and adduct molded articles formed from the thermoplastic composition are disclosed.

  本发明公开了一种氮内酯功能热塑性组合物。该组合物是一种氮内酯功能组合物和一种热塑性聚合物的混合物。本发明公开了一种通过大量均聚制造偶氮内酯官能团均聚物的方法，可选择同时或依次混合一种热塑性聚合物。本发明公开了一种混合偶氮内酯功能组合物和热塑性聚合物的方法。公开了由热塑性组合物形成的模塑制品和加成模塑制品。