N-(4-nitrobenzyloxycarbonyl)acetamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-nitrobenzyloxycarbonyl)acetamidine
• 英文别名: N-(p-nitrobenzyloxycarbonyl)acetamidine；(4-nitrophenyl)methyl N-ethanimidoylcarbamate
• 化学式: C₁₀H₁₁N₃O₄
• 分子量: 237.215
• InChiKey: AKYYURPUIANXHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-nitrobenzyloxycarbonyl)acetamidine 生成 (R)-3-Hydroxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine
  参考文献：
  名称：

  SUGIMURA, MASAO;SIBATA, TOMOYUKI;IINO, KOFU;TANAKA, TEHRUO;XASIMOTO, TOSI+

  摘要：

  DOI：
• 作为产物：
  描述：

  氯甲酸对硝基苄酯 、 乙脒碱 生成 N-(4-nitrobenzyloxycarbonyl)acetamidine
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Carbapenem derivatives, their preparation and their use as antibiotics
  申请人：Sankyo Company,. Limited

  公开号：US05712267A1

  公开（公告）日：1998-01-27

  Compounds of formula (I): ##STR1## wherein R.sup.1x is hydrogen or methyl, R.sup.2x is hydrogen optionally substituted aliphatic hydrocarbon or acylimidoyl, R.sup.3x is hydrogen or an ester group, and Q.sup.x is cyclic or acyclic nitrogen-containing group. The compounds are potent antibiotics which are resistant to dehydropeptidase I, and are thus useful for the treatment of many microbial infections.

  式(I)的化合物：其中R.sup.1x为氢或甲基，R.sup.2x为氢或可选择地取代的脂肪烃基或酰亚胺基，R.sup.3x为氢或酯基，Q.sup.x为环状或非环状含氮基团。这些化合物是强效抗生素，对脱氢肽酶I具有抗性，因此可用于治疗许多微生物感染。
• Piperazine compounds and antithrombotic pharmaceutical composition
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04797399A1

  公开（公告）日：1989-01-10

  The present invention relates to N-containing fused heterocyclic compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, halogen, aryl, lower alkyl, halo (lower) alkyl or nitro, R.sub.3 is lower alkylene, R.sub.4 and R.sub.5 are each lower alkylene, X is CH or N, Y is S, O, NH, C.dbd.N--OH or CO, Z is O or NH, and A is hydrogen, nitroso, amidino, a group of ##STR2## wherein R.sub.6 and R.sub.7 are each hydrogen, lower alkyl, acyl, or lower alkaneimidoyl which may be substituted with esterified carboxy, or a group of the formula: --N.dbd.R.sub.8, wherein R.sub.8 is lower alkylidene which may be substituted with aryl optionally substituted with suitable substituent(s). The compounds are useful for treatment of thrombosis, inflammation, or allergic disease.

  本发明涉及具有以下结构的N-含杂环化合物：##STR1## 其中R.sub.1和R.sub.2分别是氢、卤素、芳基、较低烷基、卤代(较低)烷基或亚硝基，R.sub.3是较低烷基，R.sub.4和R.sub.5分别是较低烷基，X是CH或N，Y是S、O、NH、C.dbd.N--OH或CO，Z是O或NH，A是氢、亚硝基、酰胺基，或##STR2## 中的一种，其中R.sub.6和R.sub.7分别是氢、较低烷基、酰基或可能被酯化羧基取代的较低烷基酰胺基，或者是--N.dbd.R.sub.8的一种，其中R.sub.8是可能被芳基取代的较低烷基亚烷基，该芳基可能被适当取代基取代。这些化合物可用于治疗血栓形成、炎症或过敏性疾病。
• N-containing fused heterocyclic compounds, processes for the preparation thereof and pharmaceutical compositions comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0232740A1

  公开（公告）日：1987-08-19

  A coumpound of the formula: wherein R1 and R2 are each hydrogen, halogen, aryl, lower alkyl, halo(lower)alkyl or nitro, R3 is lower alkylene, R4 and R5 are each lower alkylene, X is CH or N, Y is S, 0, NH, C= N-OH or CO, Z is O or NH, and A is hydrogen, nitroso, amidino, a group of the formula: or a group of the formula:-N=R8, pharmaceutically acceptable salts thereof, processes for the preparation thereof, pharmaceutical compositions comprising the same and their use as pharmaceuticals.

  以下式子的化合物 式中 R1 和 R2 分别为氢、卤素、芳基、低级烷基、卤代（低级）烷基或硝基、 R3 是低级烯烃 R4 和 R5 各自是低级亚烷基、 X 是 CH 或 N、 Y 是 S、0、NH、C= N-OH 或 CO、 Z 是 O 或 NH，以及 A 是氢、亚硝基、脒基、式中的一个基团： 或式：-N=R8 的基团、其药学上可接受的盐、其制备工艺、包含这些物质的药物组合物及其作为药物的用途。
• 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics
  申请人：Sankyo Company Limited

  公开号：EP0518558A1

  公开（公告）日：1992-12-16

  Compounds of formula (I): in which: R¹ is hydrogen or an unsubstituted or substituted alkyl group; and A represents a number of cyclic or acyclic nitrogen-containing groups are valuable antibiotics which are resistant to dehydropeptidase I in vivo. Methods of preparing the compounds and of using them are also disclosed.

  式(I)化合物： 其中R¹ 是氢或未取代或取代的烷基；A 代表若干环状或无环状含氮基团，这些化合物是对体内脱氢肽酶 I 具有抗性的有价值的抗生素。还公开了制备和使用这些化合物的方法。
• 1-METHYLCARBAPENEM DERIVATIVES
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0900797A1

  公开（公告）日：1999-03-10

  [Constitution] A 1-methylcarbapenem compound represented by the following formula: [wherein R1 represents a hydrogen atom or a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a hydrogen atom, a lower alkyl group, a lower alkyl group which has a substituent, a cycloalkyl group or a group of formula -C(=NH)R4 (in which R4 represents a hydrogen atom, a lower alkyl group or an amino group)]; or a pharmacologically acceptable salt or derivative thereof. [Advantages] The 1-methylcarbapenem compounds of the present invention exhibit excellent antibacterial activity and are therefore effective as a preventive or remedy of infections.

  [组织结构］ 由下式代表的1-甲基碳青霉烯类化合物： [其中 R1 代表氢原子或低级烷基，R2 代表氢原子或低级烷基，R3 代表氢原子、低级烷基、具有取代基的低级烷基、环烷基或式 -C(=NH)R4 的基团（其中 R4 代表氢原子、低级烷基或氨基）]；或其药理学上可接受的盐或衍生物。 优点 本发明的 1-甲基碳青霉烯化合物具有优异的抗菌活性，因此可有效预防或治疗感染。