3-Pyridinesulfonamide, 2-(4-morpholinyl)- | 90811-11-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Pyridinesulfonamide, 2-(4-morpholinyl)-
• 英文别名: 2-morpholin-4-ylpyridine-3-sulfonamide
• CAS: 90811-11-3
• 化学式: C₉H₁₃N₃O₃S
• mdl: MFCD18426032
• 分子量: 243.29
• InChiKey: WEDUPJFHIKEMKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  93.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] SPIRO[CYCLOPENTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS<br/>[FR] DÉRIVÉS SPIRO[CYCLOPENTANE-1,3'-INDOLIN]-2'-ONE UTILISÉS EN TANT QU'INHIBITEURS DE BROMODOMAINES
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2018109650A1

  公开（公告）日：2018-06-21

  The present invention provides spiro[cyclopentaneane-1,3'-indolin]-2'-one derivatives of formula (I), which are therapeutically useful, more particularly as bromodomain inhibitors. (I) wherein Cy, R1, R2, L and 'm' have the meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use as bromodomain inhibitors in the treatment and prevention of the associated diseases or disorders. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the spiro[cyclopentane-1,3'-indolin]-2'-one derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefore.

  本发明提供了式(I)的螺[环戊烷-1,3'-吲哚]-2'-酮衍生物，其在治疗上具有用途，更具体地作为溴结构域抑制剂。其中Cy、R1、R2、L和'm'在说明书中给出的含义，以及它们的药学上可接受的盐或药学上可接受的立体异构体，在治疗和预防疾病或紊乱方面具有用途，特别是它们作为溴结构域抑制剂在治疗和预防相关疾病或紊乱方面的用途。本发明还提供了该化合物的制备以及包括至少一种式(I)的螺[环戊烷-1,3'-吲哚]-2'-酮衍生物的药物配方，以及药学上可接受的载体、稀释剂或赋形剂。
• [EN] PYRIDINE-3-SULFONAMIDE COMPOUNDS AS PI3-KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDINE-3-SULFONAMIDE UTILISÉS EN TANT QU'INHIBITEURS DE PI3-KINASE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2019020657A1

  公开（公告）日：2019-01-31

  The invention is directed to compounds of formula (I) and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

  这项发明涉及式(I)的化合物及其盐。这些化合物是激酶活性抑制剂，特别是PI3激酶活性抑制剂。
• [EN] CHEMICAL COMPOUNDS AS INHIBITORS OF KINASE ACTIVITY<br/>[FR] COMPOSÉS CHIMIQUES COMME INHIBITEURS DE L'ACTIVITÉ KINASE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2017137535A1

  公开（公告）日：2017-08-17

  The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): (I) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3- kinase activity.

  本发明涉及某些新颖化合物。具体而言，本发明涉及式(I)的化合物及其盐。本发明的化合物是激酶活性抑制剂，特别是PI3-激酶活性的抑制剂。
• CHEMICAL COMPOUNDS AS INHIBITORS OF KINASE ACTIVITY
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3414228A1

  公开（公告）日：2018-12-19