1,3,5,7,9,11-Hexabromocyclododecane | 1093632-34-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1,3,5,7,9,11-Hexabromocyclododecane
• CAS: 1093632-34-8
• 化学式: C₁₂H₁₈Br₆
• 分子量: 641.7
• InChiKey: LEOCKULGXOQRTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  514.1±50.0 °C(Predicted)
• 密度：
  2.145±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

溴主要通过吸入进入人体，但也可以通过皮肤接触。溴盐可以摄入。由于溴的活性，它会迅速形成溴化物并可能沉积在组织中，取代其他卤素。

Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

溴是一种强大的氧化剂，能够从粘膜的水分中释放出氧自由基。这些自由基也是有力的氧化剂，能够造成组织损伤。此外，氢溴酸和溴酸的形成将导致二次刺激。溴离子还已知会影响中枢神经系统，导致溴中毒。这被认为是溴离子取代神经递质和传输系统中的氯离子的结果，从而影响许多突触过程。（L626, L627, A543）

Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

溴蒸气会引起刺激和对粘膜的直接损害。元素溴也会烧伤皮肤。溴化物离子是一种中枢神经系统抑制剂，长期暴露会产生神经元效应。这被称为溴中毒，可能导致从中睡意到昏迷、恶病质、昏迷、反射丧失或病理反射、阵挛性癫痫、震颤、共济失调、神经敏感性丧失、瘫痪、眼乳头水肿、言语异常、脑水肿、谵妄、攻击性和精神病的中心反应。

Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L626）；吸入（L626）；皮肤给药（L626）

Oral (L626) ; inhalation (L626) ; dermal (L626)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

溴蒸气会引起刺激和直接损害粘膜。症状包括流泪、流鼻涕、眼部刺激伴有来自咽和上呼吸道的粘液分泌、咳嗽、呼吸困难、窒息、喘息、鼻出血和头痛。溴离子是一种中枢神经系统抑制剂，会引起共济失调、言语不清、震颤、恶心、呕吐、乏力、眩晕、视觉障碍、不稳、头痛、记忆和注意力受损、定向障碍和幻觉。这被称为溴中毒。

Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)

来源:Toxin and Toxin Target Database (T3DB)

文献信息

• Compositions and methods for reducing fire hazard of flammable refrigerants
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2455438A2

  公开（公告）日：2012-05-23

  The present invention relates to compositions comprising flammable refrigerant, fire hazard-reducing agent, and optionally a lubricant suitable for use in a refrigeration or air conditioning apparatus. Further, the present invention relates to compositions comprising lubricant and fire hazard-reducing agent and methods for reducing flammability of flammable refrigerant, for delivering a fire hazard-reducing agent to a refrigeration or air conditioning apparatus, and for replacing a non-flammable refrigerant with a flammable refrigerant.

  本发明涉及由易燃制冷剂、火灾危险降低剂和润滑剂组成的适用于制冷或空调设备的组合物。此外，本发明还涉及包含润滑剂和火灾危险降低剂的组合物，以及降低易燃制冷剂可燃性的方法、向制冷或空调设备输送火灾危险降低剂的方法和用易燃制冷剂替代不易燃制冷剂的方法。
• Novel flame-retardant composition for polystyrenic compounds
  申请人：Lorenzi, Micaela

  公开号：EP2557115A1

  公开（公告）日：2013-02-13

  A flame-retardant composition for a polystyrene foam or a high impact polystyrene-based compound consisting exclusively of a single brominated compound (R1) and by a nitrogen- and bromine-free single free radical generator synergistic agent (R2). The single brominated compound (R1) is formed exclusively by tetrabromobisphenol A-bis (2,3-dibromopropylether), while the synergistic agent (R2) is formed exclusively by 2,3-dimethyl-2,3-diphenylbutane and/or Bis (1-methyl-1-phenylethyl) peroxide. The composition is free of antimony trioxide and hexabromocyclododecane. The weight ratio between tetrabromobisphenol A bis (2,3-dibromopropylether) and said synergistic agent (R1: R2) is of 100:1 and 1:2.

  一种用于聚苯乙烯泡沫塑料或高抗冲聚苯乙烯基化合物的阻燃组合物，完全由单一溴化化合物（R1）和不含氮和溴的单一自由基发生器增效剂（R2）组成。单一溴化化合物（R1）完全由四溴双酚 A-双（2,3-二溴丙基醚）形成，而增效剂（R2）完全由 2,3-二甲基-2,3-二苯基丁烷和/或双（1-甲基-1-苯基乙基）过氧化物形成。组合物不含三氧化二锑和六溴环十二烷。四溴双酚 A 双（2,3-二溴丙基醚）与所述增效剂（R1：R2）的重量比为 100:1 和 1:2。
• NEW FLAME RETARDANT COMPOSITION FOR HIGH IMPACT POLYSTYRENE-BASED COMPOUNDS
  申请人：Lorenzi, Micaela

  公开号：EP3029096A1

  公开（公告）日：2016-06-08

  A flame-retardant composition for a high impact polystyrene-based compound consisting exclusively of a single brominated compound (R1) and by a nitrogen- and bromine-free single free radical generator synergistic agent (R2). The single brominated compound (R1) is formed exclusively by tetrabromobisphenol A-bis (2,3-dibromopropylether), while the synergistic agent (R2) is formed exclusively by 2,3-dimethyl-2,3-diphenylbutane and/or Bis (1-methyl-1-phenylethyl) peroxide. The composition is free of antimony trioxide and hexabromocyclododecane. The weight ratio between tetrabromobisphenol A bis (2,3-dibromopropylether) and said synergistic agent (R1: R2) is of 100:1 and 1:2.

  一种用于高抗冲聚苯乙烯基化合物的阻燃组合物，完全由单一溴化化合物（R1）和不含氮和溴的单一自由基发生器增效剂（R2）组成。单一溴化化合物（R1）完全由四溴双酚 A-双（2,3-二溴丙基醚）形成，而增效剂（R2）完全由 2,3-二甲基-2,3-二苯基丁烷和/或双（1-甲基-1-苯基乙基）过氧化物形成。组合物不含三氧化二锑和六溴环十二烷。四溴双酚 A 双（2,3-二溴丙基醚）与所述增效剂（R1：R2）的重量比为 100:1 和 1:2。
• COMPOSITIONS AND METHODS FOR REDUCING FIRE HAZARD OF FLAMMABLE REFRIGERANTS
  申请人：E.I. DUPONT DE NEMOURS AND COMPANY

  公开号：EP1685210A1

  公开（公告）日：2006-08-02
• Compositions and Methods for Reducing Fire Hazard of Flammable Refrigerants
  申请人：Leck Thomas J

  公开号：US20090278097A1

  公开（公告）日：2009-11-12

  The present invention relates to compositions comprising flammable refrigerant, fire hazard-reducing agent, and optionally a lubricant suitable for use in a refrigeration or air conditioning apparatus. Further, the present invention relates to compositions comprising lubricant and fire hazard-reducing agent and methods for reducing flammability of flammable refrigerant, for delivering a fire hazard-reducing agent to a refrigeration or air conditioning apparatus, and for replacing a non-flammable refrigerant with a flammable refrigerant.