2-(2.4.6-Triiod-3.5-bis-acetamino-benzoyloxy)-buttersaeure | 15082-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2.4.6-Triiod-3.5-bis-acetamino-benzoyloxy)-buttersaeure
• 英文别名: ethyl(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)acetate；2-(3,5-Diacetamido-2,4,6-triiodobenzoyl)oxybutanoic acid
• CAS: 15082-59-4
• 化学式: C₁₅H₁₅I₃N₂O₆
• 分子量: 700.007
• InChiKey: INYVNDWRBRHIGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• X-ray contrast compositions useful in medical imaging
  申请人：NanoSystems L.L.C.

  公开号：EP0498482A2

  公开（公告）日：1992-08-12

  An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver, spleen, kidney or lymph nodes. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.

  一种 X 射线造影剂组合物，其颗粒主要由一种非放射性结晶有机 X 射线造影剂组成，该造影剂表面吸附有表面改性剂，其吸附量足以保持有效平均粒径小于 400 纳米，该组合物还包括一种药学上可接受的载体，可用于 X 射线诊断医学成像方法。这些制剂可被输送到特定的组织或液体部位，例如血液池、肝脏、脾脏、肾脏或淋巴结。在一个涉及静脉给药的实施方案中，优选的组合物可在相当长的时间内对血液池进行有效成像。
• Surface modified drug nanoparticles
  申请人：NanoSystems L.L.C.

  公开号：EP0499299A2

  公开（公告）日：1992-08-19

  Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

  主要由结晶药物物质组成的可分散微粒，其表面吸附有表面改性剂，其吸附量足以使有效平均粒径小于约 400 nm。含有这种微粒的药物组合物具有意想不到的生物利用度，可用于治疗哺乳动物。
• NOVEL CORE-SHELL STRUCTURE
  申请人：Mitsubishi Chemical Corporation

  公开号：EP1837015A1

  公开（公告）日：2007-09-26

  To provide a new structure-dispersed composite in which a substance poorly soluble in a medium is dispersed as micronized particles, a core-shell structure is dispersed in the medium, wherein said core-shell structure contains microparticles therein, and consists of a core comprising a core compound that is poorly soluble in said medium and a liquid shell comprising a shell compound that is poorly soluble in said medium, and the mean diameter of said core-shell structure is 10 µm or less.

  提供一种新的结构-分散复合材料，在该复合材料中，一种难溶于介质的物质以微粉化颗粒的形式分散，一种芯-壳结构分散在介质中，其中所述芯-壳结构包含微颗粒，并由一个包含难溶于所述介质的芯化合物的芯和一个包含难溶于所述介质的壳化合物的液壳组成，所述芯-壳结构的平均直径为 10 µm 或更小。
• GRANULE DISPERSION COMPOSITION, PROCESS FOR PRODUCING THE SAME, AND GRANULAR MATERIAL AND MEDICINE
  申请人：Mitsubishi Chemical Corporation

  公开号：EP1908511A1

  公开（公告）日：2008-04-09

  The subject matter of the present invention is to provide a new particulate material dispersion composite in which a material poorly soluble in water is micronized and dispersed. For the above purpose, a particulate material dispersion composite is produced in the present invention, wherein a particulate material containing a specific material which is poorly soluble in water, a polymer and a lipid is dispersed in water, the mean diameter of said particulate material is 1 µm or less, and the ratio of the combined weight of said polymer and said lipid to the weight of said specific material is 1.5 or larger.

  本发明的目的是提供一种新的微粒材料分散复合材料，在这种复合材料中，一种难溶于水的材料被微粉化并分散。为实现上述目的，本发明生产了一种微粒材料分散复合材料，其中含有难溶于水的特定材料、聚合物和脂质的微粒材料被分散在水中，所述微粒材料的平均直径为 1 µm 或更小，所述聚合物和所述脂质的总重量与所述特定材料的重量之比为 1.5 或更大。
• METHOD OF PRODUCING MICROPARTICLES TO BE INGESTED INTO THE BODY, MICROPARTICLES TO BE INGESTED INTO THE BODY AND DISPERSION AND MEDICINAL COMPOSITION CONTAINING THE SAME
  申请人：M Technique Co., Ltd.

  公开号：EP2177210A1

  公开（公告）日：2010-04-21

  A method of separating biologically ingestible microparticles is used to obtain biologically ingestible microparticles in a thin film fluid formed between two processing surfaces provided with a solution containing a first solvent in which an objective substance to be pulverized is dissolved and a solvent capable of serving as a second solvent in which the solubility of the microparticles is lower than in the first solvent, the two processing surfaces being arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. In the method for producing biologically ingestible microparticles by separating raw materials of biologically ingestible microparticles by a neutralization reaction in a fluid, the fluid is formed into a thin film fluid between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, and biologically ingestible microparticles are separated by a neutralization reaction in the thin film fluid. A solution containing a first solvent in which a chemical as a main eye drop component is dissolved, and a solvent capable of serving as a second solvent in which the solubility of the chemical is lower than in the first solvent, are mixed in a thin film fluid formed between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, thereby separating drug particles and providing suspended eye drops based on the drug particles.

  一种分离生物可摄取微粒的方法用于在薄膜流体中获得生物可摄取微粒，薄膜流体形成于两个加工表面之间，加工表面上有溶液，溶液中含有第一种溶剂，待粉碎的目标物质溶解在第一种溶剂中，还有一种溶剂可作为第二种溶剂，微粒在第二种溶剂中的溶解度低于在第一种溶剂中的溶解度，两个加工表面布置成能够相互接近和分离，其中至少一个加工表面相对于另一个加工表面旋转。 在通过在流体中的中和反应分离生物可摄取微粒的原料来生产生物可摄取微粒的方法中，流体在两个加工表面之间形成薄膜流体，这两个加工表面的布置使其能够相互接近和分离，其中至少一个加工表面相对于另一个加工表面旋转，生物可摄取微粒通过薄膜流体中的中和反应分离。 在两个加工表面之间形成的薄膜流体中混合含有第一溶剂的溶液，第一溶剂中溶解有作为眼药水主要成分的化学物质，第二溶剂中该化学物质的溶解度低于第一溶剂中的溶解度。