1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-4-methylpiperidine | 1221901-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-4-methylpiperidine
• CAS: 1221901-52-5
• 化学式: C₂₆H₂₄NO₂P
• 分子量: 413.456
• InChiKey: UMSJRRWJIRTJJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 (R)-(1,1′-联萘-2,2′-二氧)氯膦 在 base 作用下， 以 四氢呋喃 为溶剂， 生成 1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-4-methylpiperidine
  参考文献：
  名称：

  Influence of Phosphoramidites in Copper-Catalyzed Conjugate Borylation Reaction

  摘要：

  Copper(I) has become the preferred metal to catalyze the beta-boration of alpha,beta-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites and phosphites, can be convenient alternative ligands to induce asymmetry in the enantioselective version of this reaction, particularly in the beta-boration of alpha,beta-unsaturated imines.

  DOI：

  10.1021/om300194k
• 作为试剂：
  描述：

  3-methyl-1,5-diphenyl-2-azapenta-2,4-diene 、 联硼酸频那醇酯 在 甲醇 、 1-(12,14-Dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-4-methylpiperidine 、 sodium t-butanolate 、 [Cu(MeCN)₄](OTf) 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 1-phenyl-N-(4-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-2-ylidene)methanamine 、 1-phenyl-N-(4-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-2-ylidene)methanamine
  参考文献：
  名称：

  Influence of Phosphoramidites in Copper-Catalyzed Conjugate Borylation Reaction

  摘要：

  Copper(I) has become the preferred metal to catalyze the beta-boration of alpha,beta-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites and phosphites, can be convenient alternative ligands to induce asymmetry in the enantioselective version of this reaction, particularly in the beta-boration of alpha,beta-unsaturated imines.

  DOI：

  10.1021/om300194k