4,6-二溴吡啶甲酸 | 1060815-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4,6-二溴吡啶甲酸
• 英文名称: 4,6-Dibromopicolinic acid
• 英文别名: 4,6-dibromopyridine-2-carboxylic acid
• CAS: 1060815-78-2
• 化学式: C₆H₃Br₂NO₂
• 分子量: 280.9
• InChiKey: JZBBTBXKBJVIRC-UHFFFAOYSA-N

物化性质

• 沸点：
  396.6±42.0 °C(Predicted)
• 密度：
  2.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Diagnosis by determination of hyperactivity or increased expression of members of cell signaling pathways
  申请人：Schuller M. Hildegard

  公开号：US20060233705A1

  公开（公告）日：2006-10-19

  A non-invasive method for determining the presence or severity of a bodily disorder associated with hyperactivity or increased expression of a signal transduction protein, transcription factor, or protein kinase that is a member of the MAPK or GPCR pathways. A reagent that binds to such a signal transduction protein, transcription factor, or protein kinase is non-invasively contacted to a tissue or fluid within the body of a subject or to a fluid removed from a subject, the reagent is permitted to bind to the signal transduction protein, transcription factor, or protein kinase in the tissue or fluid, the presence of binding of the reagent to the signal transduction protein, transcription factor, or protein kinase in said tissue or fluid is determined, and the binding is correlated with the presence or severity of said bodily disorder within the subject.

  一种非侵入性方法，用于确定是否存在或严重存在与信号转导蛋白、转录因子或蛋白激酶（属于 MAPK 或 GPCR 通路的成员）活性亢进或表达增加有关的身体失调。将与这种信号转导蛋白、转录因子或蛋白激酶结合的试剂非侵入性地接触受试者体内的组织或液体，或接触从受试者体内取出的液体，允许试剂与组织或液体中的信号转导蛋白、转录因子或蛋白激酶结合、测定试剂与所述组织或液体中的信号转导蛋白、转录因子或蛋白激酶的结合情况，并将结合情况与受试者体内所述身体失调的存在或严重程度相关联。