2-(4-bromophenyl)-3-phenylquinazolin-4(3H)-one | 1159265-28-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-bromophenyl)-3-phenylquinazolin-4(3H)-one
• 英文别名: 2-(4-bromophenyl)-3-phenyl-4(3H)-Quinazolinone；2-(4-bromophenyl)-3-phenylquinazolin-4-one
• CAS: 1159265-28-7
• 化学式: C₂₀H₁₃BrN₂O
• 分子量: 377.24
• InChiKey: OSGDSWOTVGMMBH-UHFFFAOYSA-N

物化性质

• 沸点：
  511.4±52.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-硝基苯甲酰氯 在 1,1'-双(二苯基膦)二茂铁 、 三乙胺 作用下， 以 二氯甲烷 、 氯苯 为溶剂， 反应 26.0h， 生成 2-(4-bromophenyl)-3-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Iron-Catalyzed One-Pot 2,3-Diarylquinazolinone Formation from 2-Nitrobenzamides and Alcohols

  摘要：

  A novel approach for the synthesis of 2,3-diarylquinazolinones using iron as catalyst is described. Various 2-nitro-N-arylbenzamides reacted with benzylic alcohols to selectively give the corresponding products in the absence of external oxidant or reductant.

  DOI：

  10.1021/ol402350x

文献信息

• Complementary Reactivity in Selective Radical Processes: Electrochemistry of Oxadiazolines to Quinazolinones
  作者：Ho Seong Hwang、Eun Jin Cho

  DOI：10.1021/acs.orglett.1c01676

  日期：2021.7.2

  Electrochemistry has recently emerged as a sustainable approach for efficiently generating radical intermediates utilizing eco-friendly electric energy. An electrochemical process was developed to transform 1,2,4-oxadiazolines under mild conditions. The electrochemical N–O bond cleavage at a controlled oxidation potential led to the selective synthesis of quinazolinone derivatives that could not be

  电化学最近已成为利用环保电能有效生成自由基中间体的可持续方法。开发了一种在温和条件下转化 1,2,4-恶二唑啉的电化学过程。在受控氧化电位下电化学 N-O 键断裂导致选择性合成喹唑啉酮衍生物，而光催化自由基过程无法获得，这表明自由基过程中存在互补的反应性。基于密度泛函理论的研究充分揭示了电化学反应途径。
• Old dye safranine as an organic photocatalyst for the synthesis of substituted quinazolinones
  作者：Cheng-Hang Liu、Jun-Jie Wang、Mengyang Xu、Qiyun Luo、Ziyan Wang、Wenyue Tan、Xingzeng Zhao、Xiaodong Jia

  DOI：10.1039/d3nj05683j

  日期：——

  Safranine-catalyzed oxidative cyclization reaction of substituted 2-aminobenzamides and aldehydes utilizing oxygen as a green oxidant under visible light conditions at room temperature has been developed. Good to excellent yields of the desired quinazolinone products were achieved. Furthermore, the presented procedure illustrates the applicability of gram scale reactions.

  开发了番红催化的取代 2-氨基苯甲酰胺和醛的氧化环化反应，利用氧气作为绿色氧化剂，在可见光条件下在室温下进行。获得了所需喹唑啉酮产物的良好至优异的产率。此外，所提出的程序说明了克级反应的适用性。
• Materials for organic electroluminescent devices
  申请人：Merck Patent GmbH

  公开号：US10544360B2

  公开（公告）日：2020-01-28

  The present invention relates to mixtures comprising at least one phosphorescent dopant and at least one compound of one of the formulae (1) and (2), and the use thereof in electronic devices, especially in organic electroluminescent devices.

  本发明涉及由至少一种磷光掺杂剂和至少一种式（1）和式（2）之一的化合物组成的混合物，及其在电子设备中的应用，特别是在有机电致发光设备中的应用。
• T3P catalyzed one pot three-component synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
  作者：Goravanahalli M. Raghavendra、Chottanahalli S. Pavan Kumar、Gejjalagere P. Suresha、Kanchugarakoppal S. Rangappa、Kempegowda Mantelingu

  DOI：10.1016/j.cclet.2015.03.037

  日期：2015.8

  An efficient methodology for the synthesis of 2,3-disubstituted 3H-quinazolin-4-ones is described via one-pot three component reaction from anthranilic acid using T3P as catalyst. Mild reaction conditions, short reaction time, broad functional group tolerance, easy isolation of products and good yields are main advantages of this protocol. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
• MATERIALIEN FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN
  申请人：Merck Patent GmbH

  公开号：EP3197982A1

  公开（公告）日：2017-08-02