Benzoic acid, 4-[[imino[(4-nitrophenyl)amino]methyl]amino]- | 71431-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid, 4-[[imino[(4-nitrophenyl)amino]methyl]amino]-
• 英文别名: 4-[[N'-(4-nitrophenyl)carbamimidoyl]amino]benzoic acid
• CAS: 71431-10-2
• 化学式: C14H12N4O4
• 分子量: 300.27
• InChiKey: FHKFBENPBIWOLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods for modulating cell-to-cell adhesion using an agonist of C1INH-type protein activity
  申请人：Davis E. Alvin

  公开号：US20060142187A1

  公开（公告）日：2006-06-29

  The present invention is based, at least in part, on the discovery that plasma C1INH contains a sialyl Lewis x related moiety on its N-glycan and is capable of binding selectin molecules. The invention provides methods for modulating cell-to-cell adhesion or cell migration comprising contacting a cell with a C1INH-type protein or fragment thereof or a nucleic acid encoding a C1INH-type protein or fragment thereof, such that cell-to-cell adhesion is modulated. The invention also provides methods for treating or preventing cell adhesion related disorders in a subject comprising administering to the subject an effective amount of a C1INH-type protein or fragment thereof or a nucleic acid encoding a C1INH-type protein or fragment thereof.
• 14094, a novel human trypsin family member and uses thereof
  申请人：Meyers Rachel

  公开号：US20070009433A1

  公开（公告）日：2007-01-11

  The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.
• US7071004B1
  申请人：——

  公开号：US7071004B1

  公开（公告）日：2006-07-04
• [EN] EXOSITE ASSAY FOR ANTICOAGULANTS<br/>[FR] ANALYSE HORS SITE D'ANTICOAGULANTS
  申请人：EMORY UNIVERSITY

  公开号：WO1998055130A1

  公开（公告）日：1998-12-10

  (EN) Formation of blood clots requires the catalytic formation of the protein thrombin, and applicant has developed a biochemical assay to measure certain exosite interactions of the prothrombinase complex involved in such catalytic formation.(FR) La formation de caillots sanguins est tributaire de la formation catalytique de la protéine 'thrombine'. Cette invention concerne une analyse biochimique qui permet de mesurer certaines interactions hors site du complexe de prothrombinase jouant un rôle dans cette formation catalytique.
• [EN] METHODS FOR MODULATING CELL-TO-CELL ADHESION USING AN AGONIST OF C1INH-TYPE PROTEIN ACTIVITY<br/>[FR] METHODES DE MODULATION DE L'ADHESION DE CELLULE A CELLULE A L'AIDE D'UN AGONISTE D'ACTIVITE PROTEIQUE DE TYPE C1INH
  申请人：CBR INST FOR BIOMED RES INC

  公开号：WO2004110356A2

  公开（公告）日：2004-12-23

  The present invention is based, at least in part, on the discovery that plasma C1D411 contains a sialyl Lewis' related moiety on its N-glycan and is capable of binding selectin molecules. The invention provides methods for modulating cell-to-cell adhesion or cell migration comprising contacting a cell with a C1INH-type protein or fragment thereof or a nucleic acid encoding a C1INH-type protein or fragment thereof, such that cell-to-cell adhesion is modulated. The invention also provides methods for treating or preventing cell adhesion related disorders in a subject comprising administering to the subject an effective amount of a C1INH-type protein or fragment thereof or a nucleic acid encoding a C1INH-type protein or fragment thereof.