3,4-dihydroxybenzoic acid monohydrate | 86414-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dihydroxybenzoic acid monohydrate
• 英文别名: 3,4-dihydroxybenzoic acid;hydrate
• CAS: 86414-76-8
• 化学式: C₇H₆O₄*H₂O
• 分子量: 172.138
• InChiKey: VTZSLCWNENCYDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.03
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
  申请人：Philippe Michel

  公开号：US20100028280A1

  公开（公告）日：2010-02-04

  The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

  该发明涉及一种直发角蛋白纤维的拉直过程，包括：(i)将至少两种变性剂含有的拉直组合物涂抹到角蛋白纤维上的步骤，(ii)使用加热装置将角蛋白纤维的温度升高至110至250°C的步骤。
• 1,3-BENZODIOXOLE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3121175A1

  公开（公告）日：2017-01-25

  The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent inhibitory effect on EZH1 and/or EZH2 activity. The present invention provides a compound having a 1,3-benzodioxole structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a pharmaceutical composition comprising the compound (wherein R1, R2, R3, R4, R5, R6, and V in the formula (I) are each as defined in the present specification).

  本发明提供了一种具有特定化学结构的化合物或其药理学上可接受的盐，该化合物对 EZH1 和/或 EZH2 的活性具有极佳的抑制作用。本发明提供了一种具有通式（I）所代表的 1，3-苯并二恶茂结构的化合物或其药理学上可接受的盐，或包含该化合物的药物组合物（其中式（I）中的 R1、R2、R3、R4、R5、R6 和 V 均如本说明书中所定义）。
• 1,3-benzodioxole derivative
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US10017500B2

  公开（公告）日：2018-07-10

  The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent inhibitory effect on EZH1 and/or EZH2 activity. The present invention provides a compound having a 1,3-benzodioxole structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a pharmaceutical composition comprising the compound (wherein R1, R2, R3, R4, R5, R6, and V in the formula (I) are each as defined in the present specification).

  本发明提供了一种具有特定化学结构的化合物或其药理学上可接受的盐，该化合物对 EZH1 和/或 EZH2 的活性具有极佳的抑制作用。本发明提供了一种具有通式（I）所代表的 1，3-苯并二恶茂结构的化合物或其药理学上可接受的盐，或包含该化合物的药物组合物（其中式（I）中的 R1、R2、R3、R4、R5、R6 和 V 均如本说明书中所定义）。
• Methods of treating SARS Cov-2 virus with protocatechuic acid
  申请人：Johnson Lanny L

  公开号：US10959969B1

  公开（公告）日：2021-03-30

  The present disclosure provides methods for killing the SARS CoV-2 virus in mammals and treating the Coronavirus Disease-19 (Covid-19) in mammals including humans using compositions including protocatechuic acid. The present disclosure provides methods and pharmaceutical and nutraceutical compositions that reduce or substantially eliminate the SARS CoV-2 virus in mammals. In one embodiment, a method of treating a mammal with Covid-19 is provided comprising administering protocatechuic acid to a mammal in need of such treatment a therapeutically effective amount of a protocatechuic acid composition.

  本公开提供了使用包括原儿茶酸在内的组合物杀死哺乳动物体内的 SARS CoV-2 病毒和治疗包括人类在内的哺乳动物体内的冠状病毒疾病-19（Covid-19）的方法。本公开提供了减少或基本消除哺乳动物体内 SARS CoV-2 病毒的方法以及药物和营养保健品组合物。在一个实施方案中，提供了一种治疗哺乳动物Covid-19的方法，包括向需要治疗的哺乳动物施用治疗有效量的原儿茶酸组合物。
• Method for straightening keratinous fibers using heating means and an aromatic compound
  申请人：L'Oreal

  公开号：US11044978B2

  公开（公告）日：2021-06-29

  The invention concerns a method for straightening keratinous fibers including: (i) a step of applying on the keratinous fibers a hair straightening composition containing at least one polyhydroxylated aromatic compound, (ii) a step of increasing the temperature of the keratinous fibers, using heating means, to a temperature ranging between 110 and 250° C.

  本发明涉及一种拉直角质纤维的方法，包括：(i) 在角质纤维上涂抹含有至少一种多羟基芳香族化合物的拉直头发组合物，(ii) 使用加热装置将角质纤维的温度提高到 110 至 250 摄氏度之间。