3-Difluoromethyl-1-(5-methanesulfonyl-pyridin-2-yl)-5-(3-methylene-cyclopentylmethoxy)-1 H-pyrazole-4-carbonitrile | 521059-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Difluoromethyl-1-(5-methanesulfonyl-pyridin-2-yl)-5-(3-methylene-cyclopentylmethoxy)-1 H-pyrazole-4-carbonitrile
• 英文别名: 3-(Difluoromethyl)-5-[(3-methylidenecyclopentyl)methoxy]-1-(5-methylsulfonylpyridin-2-yl)pyrazole-4-carbonitrile
• CAS: 521059-41-6
• 化学式: C₁₈H₁₈F₂N₄O₃S
• 分子量: 408.429
• InChiKey: IJFACVSZKORRIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• 5-(Alkylidene-cycloalkyl)-and 5-(alkylidene-heterocyclyl)-pyrazoles
  申请人：——

  公开号：US20030134839A1

  公开（公告）日：2003-07-17

  The present invention relates to 5-(alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I: 1 wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, B, ring G, R 1 through R 7 are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

  本发明涉及式I的5-(烷基亚甲基环烷基)-吡唑和5-(烷基亚甲基杂环基)-吡唑，其中式(R5)-A-(SOmR4)的环，m，B，环G，R1至R7如规范中所定义的，以及包含它们的制药组合物和它们的药用用途。本发明的化合物在哺乳动物，特别是人类，狗，猫和家畜动物中治疗或缓解炎症和其他炎症相关疾病，如关节炎，结肠癌和阿尔茨海默病中有用。
• 5-(alkylidene-cycloalkyl)- and 5-(alkylidene-heterocyclyl)-pyrazoles
  申请人：Pfizer Products Inc.

  公开号：EP1308446B1

  公开（公告）日：2004-12-08
• US6838458B2
  申请人：——

  公开号：US6838458B2

  公开（公告）日：2005-01-04
• [EN] 1-(5-SULFONYL-PYRIDIN-2-YL)-5-(METHYLIDENE-CYCLOALKYLMETHOXY)-1H-PYRAZOLE-4-CARBONITRILE DERIVATIVES AND OTHER COMPOUNDS AS CYCLOOXYGENASE INHIBITORS FOR THE TREATMENT OF ARTHRITIS, NEURODEGENERATION AND COLON CANCER<br/>[FR] DERIVES DE 1-(5-SULFONYL-PYRIDIN-2-YL)-5-(METHYLIDENE-CYCLOALKYLMETHOXY)-1H-PYRAZOLE-4-CARBONITRILE ET AUTRES COMPOSES UTILISES EN TANT QU'INHIBITEURS DE LA CYCLOOXYGENASE DANS LE TRAITEMENT DE L'ARTHRITE, DE LA NEURODEGENERATION ET DU CANCER DU COLON
  申请人：PFIZER PROD INC

  公开号：WO2003037336A1

  公开（公告）日：2003-05-08

  The present invention relates to 5-alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I, wherein the ring of the formula (R5)-A-SO¿mR?4), m, B, ring G, R1 through R7 are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.