3-(3-fluoro-5-trifluoromethyl-phenyl)-propan-1-one | 955403-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-fluoro-5-trifluoromethyl-phenyl)-propan-1-one
• 英文别名: Benzenepropanal, 3-fluoro-5-(trifluoromethyl)-；3-[3-fluoro-5-(trifluoromethyl)phenyl]propanal
• CAS: 955403-56-2
• 化学式: C₁₀H₈F₄O
• mdl: MFCD09028609
• 分子量: 220.167
• InChiKey: FMBQBEDKXDYJPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20090099228A1

  公开（公告）日：2009-04-16

  The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists.

  这项发明涉及新型吡唑并四氢吡啶化合物及其作为促进睡眠的受体拮抗剂的用途。
• HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS
  申请人：3-DIMENSIONAL PHARMACEUTICALS, INC.

  公开号：EP1150979A1

  公开（公告）日：2001-11-07
• US7834028B2
  申请人：——

  公开号：US7834028B2

  公开（公告）日：2010-11-16
• [EN] HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS<br/>[FR] AMIDINES, METHYLAMIDINES ET GUANIDINES, HETEROARYLES, EN TANT QU'INHIBITEURS DE PROTEASES
  申请人：DIMENSIONAL PHARM INC

  公开号：WO2000047578A1

  公开（公告）日：2000-08-17

  The present invention is directed to compounds of Formula (I) wherein X is O, S or NR?7 and R1-R7¿, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula (I). The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.
• [EN] NOVEL PYRAZOLO-TETRAHYDROPYRIDINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLO-TÉTRAHYDROPYRIDINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2007122591A2

  公开（公告）日：2007-11-01

  [EN] The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists.
  [FR] L'invention concerne de nouveaux composés de pyrazolo-tétrahydropyridines et leur utilisation comme antagonistes des récepteurs d'orexine.