5-bromomethyl-3-p-tolyl-[1,2,4]thiadiazole | 851224-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-bromomethyl-3-p-tolyl-[1,2,4]thiadiazole
• 英文别名: 5-(Bromomethyl)-3-(4-methylphenyl)-1,2,4-thiadiazole
• CAS: 851224-93-6
• 化学式: C₁₀H₉BrN₂S
• 分子量: 269.165
• InChiKey: GBJXDYMUIKJULH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs
  申请人：Kuo Gee-Hong

  公开号：US20050096362A1

  公开（公告）日：2005-05-05

  The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

  这项发明涉及4-((苯氧烷基)硫基)-苯氧基乙酸及其类似物，含有它们的组合物，以及将它们用作PPAR调节剂来治疗或抑制例如血脂异常等疾病进展的方法。
• [EN] PHENOXYACETIC ACIDS DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) DUAL AGONISTS<br/>[FR] DERIVES D'ACIDES PHENOXYACETIQUES UTILES EN TANT D'AGONISTES DOUBLES DU RECEPTEUR ACTIVE-PROLIFERATEUR DU PEROXYSOME (PPAR)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005041959A1

  公开（公告）日：2005-05-12

  The invention features phenoxyacetic acids and analogs of formula (I), compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

  该发明涉及公式(I)的苯氧乙酸及其类似物，包含它们的组合物，以及将它们用作PPAR调节剂以治疗或抑制例如脂质代谢异常等疾病的方法。
• 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS
  申请人：KUO Gee-Hong

  公开号：US20090131489A1

  公开（公告）日：2009-05-21

  The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

  这项发明涉及4-((苯氧烷基)硫基)-苯氧乙酸及其类似物、包含它们的组合物，以及将它们用作PPAR调节剂治疗或抑制例如脂质代谢异常等疾病进展的方法。
• PHENOXYACETIC ACIDS DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) DUAL AGONISTS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1684752B1

  公开（公告）日：2007-05-16
• BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL
  申请人：Kuo Gee-Hong

  公开号：US20100120748A1

  公开（公告）日：2010-05-13

  The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.