1-(But-1-en-1-yl)-4-fluorobenzene | 137225-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(But-1-en-1-yl)-4-fluorobenzene
• 英文别名: 1-but-1-enyl-4-fluorobenzene
• CAS: 137225-01-5
• 化学式: C₁₀H₁₁F
• 分子量: 150.19
• InChiKey: FPGCYTJCZNIGCD-UHFFFAOYSA-N

物化性质

• 沸点：
  194.8±9.0 °C(Predicted)
• 密度：
  0.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER
  申请人：Zhu Lei

  公开号：US20110306605A1

  公开（公告）日：2011-12-15

  Compounds including those of the Formula I where X, R 1 , R 2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.

  提供包括公式I中的化合物，其中X，R1，R2和下标t的定义如本文所述，这些化合物作为γ-分泌酶抑制剂有用，提供了包括这些化合物的组合物，以及使用这些化合物治疗或预防神经退行性疾病的方法，例如阿尔茨海默病。
• PHENYL ALKYL CARBAMATE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：US20130165509A1

  公开（公告）日：2013-06-27

  A phenyl alkyl carbamate derivative compound and a pharmaceutical composition containing the compound are provided. More specifically, the phenyl alkyl carbamate derivative compound and a pharmaceutically acceptable salt thereof, a composition for muscle relaxation containing the phenyl alkyl carbamate derivative compounds and/or pharmaceutically acceptable salt thereof as an active ingredient, and a method of muscle relaxation comprising administering a pharmaceutically effective amount of the phenyl alkyl carbamate derivative compound and/or a pharmaceutically acceptable salt thereof to a subject in need of to a subject in need of, are provided.

  本发明提供了一种苯基烷基氨基甲酸酯衍生物化合物及其含药物组合物。更具体地，提供了苯基烷基氨基甲酸酯衍生物化合物及其药学上可接受的盐，包含苯基烷基氨基甲酸酯衍生物化合物和/或药学上可接受的盐作为活性成分的肌肉松弛剂组合物，以及通过向需要的受试者施用苯基烷基氨基甲酸酯衍生物化合物和/或药学上可接受的盐的药学有效量来实现肌肉松弛的方法。
• PHENYL ALKYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILEPSY OR EPILEPSY-RELATED SYNDROME
  申请人：BIO-PHARM SOLUTIONS CO., LTD.

  公开号：US20160023999A1

  公开（公告）日：2016-01-28

  The present invention provides a pharmaceutical composition for preventing and/or treating a epilepsy or epilepsy-related syndrome, for example an intractable epilepsy or its related syndrome such as drug-resistant epilepsy, comprising the phenyl alkyl carbamate compound as an active ingredient, and a use of the phenyl alkyl carbamate compound for preventing and/or treating epilepsy or epilepsy-related syndrome.

  本发明提供了一种药物组合物，用于预防和/或治疗癫痫或癫痫相关综合症，例如难治性癫痫或其相关综合症，如耐药性癫痫，该组合物包括苯基烷基氨甲酸酯化合物作为活性成分，以及苯基烷基氨甲酸酯化合物用于预防和/或治疗癫痫或癫痫相关综合症的用途。
• Processes for preparing phosphonyl hydroxyacyl prolines
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0350138A2

  公开（公告）日：1990-01-10

  Processes are disclosed for preparing phosphonyl hydroxyacyl prolines from a phosphonous acid or phosphonochloridate intermediate. The compounds prepared possess angiotension converting enzyme inhibition activty and are useful as anti­hypertensive agents. This invention is also directed to orally active antihypertensive agents of the formula wherein R₁ is certain alkyl or aralkyl groups.

  本发明公开了从膦酸或膦酰氯中间体制备膦酰羟基酰基脯氨酸的工艺。所制备的化合物具有血管紧张素转换酶抑制活性，可用作降压药。 本发明还涉及式如下的口服活性降压药 其中 R₁ 是某些烷基或芳烷基。
• Phenyl alkyl carbamate derivative compound and pharmaceutical composition containing the same
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP2797881A1

  公开（公告）日：2014-11-05