US9216962, Cfh455-C | 1408235-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: US9216962, Cfh455-C
• 英文别名: 5-cyclopropyl-N-[[4-(hydroxycarbamoyl)phenyl]methyl]-2-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-1,3-thiazole-4-carboxamide
• CAS: 1408235-29-9
• 化学式: C₂₂H₂₂N₄O₃S₂
• 分子量: 454.574
• InChiKey: BRGHNGRVZSFLGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF
  申请人：Shanghai Puyi Chemical Co., Ltd.

  公开号：US20140148600A1

  公开（公告）日：2014-05-29

  The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses for treatments against tumor and multiple sclerosis as inhibitors of histone deacetylase.

  本发明涉及式I的噻唑化合物，其制备方法和用途。更具体地说，本发明涉及天然产物largazole的新衍生物，其制备方法以及作为组蛋白脱乙酰化酶抑制剂用于抗肿瘤和多发性硬化症治疗的用途。
• ARYL-2,2'-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Institute Materia Medica, Chinese Academy Of Sciences

  公开号：EP3508486A1

  公开（公告）日：2019-07-10

  The present invention relates to an aryl-2,2'-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2'-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.

  本发明涉及一种芳基-2,2'-串联双噻唑化合物及其制备方法和用途。具体而言，本发明公开了一种结构如通式 I 所示的芳基-2,2'-串联双噻唑化合物及其制备方法，以及其作为组蛋白去乙酰化酶抑制剂在制备抗肿瘤药物中的用途。
• Aryl-2,2′-tandem bisthiazole compound and preparation method and use thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US10766889B2

  公开（公告）日：2020-09-08

  The invention describes an aryl-2,2′-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2′-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.

  本发明描述了一种芳基-2,2′-串联双噻唑化合物及其制备方法和用途。特别是，本发明公开了一种结构如通式I所示的芳基-2,2′-串联双噻唑化合物及其制备方法，以及其作为组蛋白去乙酰化酶抑制剂在制备抗肿瘤药物中的用途。
• THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF
  申请人：Shanghai Theorion Pharmaceutical Co., Ltd.

  公开号：EP2708534B1

  公开（公告）日：2017-07-12
• US9216962B2
  申请人：——

  公开号：US9216962B2

  公开（公告）日：2015-12-22