(pyridin-3-yl)methoxyacetic acid | 209785-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (pyridin-3-yl)methoxyacetic acid
• 英文别名: 2-(Pyridin-3-ylmethoxy)acetic acid
• CAS: 209785-11-5
• 化学式: C₈H₉NO₃
• mdl: MFCD20658201
• 分子量: 167.164
• InChiKey: ZDVKIFPPXUCCEW-UHFFFAOYSA-N

物化性质

• 沸点：
  366.6±22.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PIPERIDINYLOXY AND PYRROLIDINYLOXYPHENYL OXAZOLIDINONES AS ANTIBACTERIALS<br/>[FR] PIPERIDINYLOXY ET PYRROLIDINYLOXYPHENYL OXAZOLIDINONES A ACTIVITE ANTIBACTERIENNE
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2001046164A1

  公开（公告）日：2001-06-28

  Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula (I): wherein R1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

  Piperidinyloxy，pyrrolidinyloxyl和azetidinyloxy化合物的化学式（I）：其中R1是piperidinyl，pyrrolidinyl或azetidinyl基团，如本文所述，并且其中的取代基具有所述描述中指示的含义。这些化合物可用作抗菌剂。
• Cell differentiation inducer
  申请人：Schering Aktiengesellschaft

  公开号：US20040147569A1

  公开（公告）日：2004-07-29

  The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma. 1

  本发明中由公式（1）表示的新型苯甲酰胺衍生物和由公式（13）表示的新型苯胺酰衍生物具有诱导分化的效果，因此可用作恶性肿瘤、自身免疫性疾病、皮肤病和寄生虫治疗或改善剂。特别是，它们对于血液恶性肿瘤和实体癌具有高度的抗癌药物效果。
• New pharmaceutical combination
  申请人：Schuppan Detlev

  公开号：US20050054647A1

  公开（公告）日：2005-03-10

  Pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at lest one compound of general formula II) or Iia), or pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at least one compound of general formula II) or Iia), and an anti-hormone, and their use for the treatment of different diseases resulting by persistent angiogenesis are described.

  本文描述了包含至少一个I-A或I-AA通用式化合物和至少一个II）或Iia）通用式化合物的制药组合物，或包含至少一个I-A或I-AA通用式化合物和至少一个II）或Iia）通用式化合物以及抗激素的制药组合物，并用于治疗由持续血管生成引起的不同疾病。
• Piperazines and Piperidines as Mglur5 Potentiators
  申请人：Slassi Abdelmalik

  公开号：US20090023711A1

  公开（公告）日：2009-01-22

  Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: wherein Ar 1 , Ar 2 , A, X, Y, m, n and R 1 , R 2 , R 3 , R 4 and R 5 are as described in the specification, processes for their preparation, pharmaceutical formulations comprising them and their use in therapy, particularly in the therapy of neurological and psychiatric disorders associated with glutamate dysfunction.

  公式I的化合物或其药学上可接受的盐或溶剂化物：其中Ar1，Ar2，A，X，Y，m，n和R1，R2，R3，R4和R5如说明书所述，其制备方法，包括它们的药物制剂以及它们在治疗中的应用，特别是在与谷氨酸功能障碍相关的神经系统和精神障碍的治疗中。
• CELL DIFFERENTIATION INDUCER
  申请人：Suzuki Tsuneji

  公开号：US20100256201A1

  公开（公告）日：2010-10-07

  The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

  本发明的公式（1）所代表的新型苯甲酰胺衍生物和公式（13）所代表的新型苯酰胺衍生物具有诱导分化的效果，因此可作为治疗或改善恶性肿瘤、自身免疫性疾病、皮肤病和寄生虫病的治疗药物或改善剂。特别是，它们对血液恶性肿瘤和实体癌具有高度的抗癌作用。