cis-[Pt(NH3)2(9-MeA)(9-MeA(-H))(Pt(NH3)3)2](5+) | 681121-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: cis-[Pt(NH3)2(9-MeA)(9-MeA(-H))(Pt(NH3)3)2](5+)
• 英文别名: cis-[Pt(ammonia)2(9-methyladenine)(9-methyladenine(-H))(Pt(ammonia)3)2](5+)
• CAS: 681121-93-7
• 化学式: C₁₂H₃₇N₁₈Pt₃
• 分子量: 1018.79
• InChiKey: OUDVCMCERNRBMM-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  cis-[Pt(NH3)2(9-MeA)2(Pt(NH3)3)2]Cl2*2H2O 在 NaOH 作用下， 以 重水 为溶剂， 生成 cis-[Pt(NH3)2(9-MeA)(9-MeA(-H))(Pt(NH3)3)2](5+)
  参考文献：
  名称：

  Migration of a cis-(NH₃)₂Pt^II Moiety along Two Adenine Nucleobases, from N1 to N6, is Markedly Facilitated by Additional Pt^II Entities Coordinated to N7

  摘要：

  Adenine acidification as a consequence of simultaneous Pt-II binding to N1 and N7 facilitates deprotonation of the exocyclic N(6)H-2 group and permits Pt-II migration from N1 to N6 under mild conditions. Starting from the trinuclear complex cis-[(NH3)(2)Pt(N1-9-MeA-N7)(2){Pt(NH3)(3))}(2)](6+) (3), stepwise migration of cis-(NH3)(2)Pt-II takes place in the alkaline aqueous solution to give initially cis- [(NH3)(2)Pt(N1-9-MeA-N7)(N6-9-MeA(-)-N7){Pt(NH3)(3)}(2)](5+) (4) and eventually cis-[(NH3)(2)Pt(N6-9-MeA(-)-N7)(2){Pt(NH3)(3)}(2)](4+) (5) (with 9-MeA = neutral 9-methyladenine, 9-MeA(-) = 9-methyladenine monoanion, deprotonated at N6). The migration process has been studied by H-1 NMR spectroscopy, and relevant acid-base equilibria have been determined. 5 has been crystallized as its nitrate salt and has been characterized by X-ray crystallography. The precursor of 3, [(NH3)(3)Pt (9-MeA-N7)]Cl-2 center dot 2H(2)O (2) has likewise been studied by X-ray analysis.

  DOI：

  10.1021/ic7008754