4-[(4-Methylphenyl)sulfonyl]-1-piperidinecarboxylic acid tert-butyl ester | 676527-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(4-Methylphenyl)sulfonyl]-1-piperidinecarboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-(4-methylphenyl)sulfonylpiperidine-1-carboxylate
• CAS: 676527-72-3
• 化学式: C₁₇H₂₅NO₄S
• 分子量: 339.5
• InChiKey: XIJJCGXCGIXHTR-UHFFFAOYSA-N

物化性质

• 沸点：
  486.7±45.0 °C(Predicted)
• 密度：
  1.177

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS<br/>[FR] DÉRIVÉS DE PYRAZOLYLE UTILES EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：NOVARTIS AG

  公开号：WO2021124222A1

  公开（公告）日：2021-06-24

  The present application provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; method for manufacturing said compound, and its therapeutic uses. The present application further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

  本申请提供了化合物的公式(I)或其立体异构体，或其对映异构体，或其可接受的药物盐，或其对映异构体的可接受的药物盐，或其对映异构体的可接受的药物盐；制造该化合物的方法及其治疗用途。本申请还提供了药理活性剂的组合以及包含该化合物的药物组合物。
• MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas Operations, Inc.

  公开号：US20220267305A1

  公开（公告）日：2022-08-25

  The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
• [EN] PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS<br/>[FR] DÉRIVÉS PYRAZOLYLE UTILES EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：NOVARTIS AG

  公开号：WO2021120890A1

  公开（公告）日：2021-06-24

  Provided is a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; a method for manufacturing said compound, and its therapeutic uses. Provided are a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.