2,2,2-trifluoro-1-fluoren-9-yl-ethanone | 386-83-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,2,2-trifluoro-1-fluoren-9-yl-ethanone
• 英文别名: 2,2,2-Trifluor-1-fluoren-9-yl-aethanon；1-(9H-Fluoren-9-yl)-2,2,2-trifluoroethan-1-one；1-(9H-fluoren-9-yl)-2,2,2-trifluoroethanone
• CAS: 386-83-4
• 化学式: C₁₅H₉F₃O
• 分子量: 262.231
• InChiKey: GMKFBDYQYADPBN-UHFFFAOYSA-N

物化性质

• 熔点：
  188-189 °C(Solv: ligroine (8032-32-4))
• 沸点：
  343.9±42.0 °C(Predicted)
• 密度：
  1.338

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三氟乙酸酐 、 fluorenylsodium 在 苯 作用下， 生成 2,2,2-trifluoro-1-fluoren-9-yl-ethanone
  参考文献：
  名称：

  Greenhow et al., Journal of the Chemical Society, 1953, p. 3099,3104

  摘要：

  DOI：

文献信息

• SMALL MOLECULES THAT INDUCE INTRINSIC PATHWAYS APOPTOSIS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20170105963A1

  公开（公告）日：2017-04-20

  Apoptosis is generally believed to be a process that requires several hours, in contrast to non-programmed forms of cell death that can occur in minutes. Our findings challenge the time-consuming nature of apoptosis. We describe herein the discovery and characterization of a small molecule, named Raptinal, which initiates intrinsic pathway caspase-dependent apoptosis within minutes, in multiple different cell lines. Comparison to a mechanistically diverse panel of apoptotic stimuli reveals Raptinal-induced apoptosis proceeds with unparalleled speed. The rapid phenotype enabled identification of the critical roles of mitochondrial voltage-dependent anion channel function, mitochondrial membrane potential/coupled respiration, and mitochondrial complex I, III and IV function for apoptosis induction. Use of Raptinal in whole organisms demonstrates its utility to study apoptosis in vivo for a variety of applications. Overall, rapid inducers of apoptosis are powerful tools that will be used in a variety of settings to generate further insight into the apoptotic machinery.
• US9682060B2
  申请人：——

  公开号：US9682060B2

  公开（公告）日：2017-06-20