Methyl5-(methylamino)pyridine-2-carboxylate | 2248396-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl5-(methylamino)pyridine-2-carboxylate
• 英文别名: methyl 5-(methylamino)pyridine-2-carboxylate
• CAS: 2248396-43-0
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: WMTMLOKCOOYGFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS
  申请人：YUMANITY THERAPEUTICS INC

  公开号：WO2020198026A1

  公开（公告）日：2020-10-01

  The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

  本发明涉及对神经系统疾病和原发性脑癌治疗中有用的化合物。本发明的化合物，单独或与其他药用活性剂结合使用，可用于治疗或预防神经系统疾病和原发性脑癌。
• [EN] 4-HETEROARYLCARBONYL-N-(PHENYL OR HETEROARYL) PIPERIDINE-1-CARBOXAMIDES AS INHIBITORS OF TANKYRASES<br/>[FR] 4-HÉTÉROARYLCARBONYL-N-(PHÉNYLE OU HÉTÉROARYL) PIPÉRIDINE-1-CARBOXAMIDES SERVANT D'INHIBITEURS DE TANKYRASES
  申请人：MERCK PATENT GMBH

  公开号：WO2020114892A1

  公开（公告）日：2020-06-11

  Compounds of the formula (I) in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, multiple sclerosis, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式（I）中R1、R2和R3具有权利要求1中所指示的含义的化合物是坦克酶的抑制剂，可以用于治疗癌症、多发性硬化症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• 4-HETEROARYLCARBONYL-N-(PHENYL OR HETEROARYL) PIPERIDINE-1-CARBOXAMIDES AS INHIBITORS OF TANKYRASES
  申请人：Merck Patent GmbH

  公开号：EP3891136A1

  公开（公告）日：2021-10-13
• CARBOXYLIC ACID DERIVATIVES
  申请人：Merck Patent GmbH

  公开号：US20220096454A1

  公开（公告）日：2022-03-31

  Compounds of the formula I in which R 1 , R 2 and R 3 have the meanings indicated in Claim 1 , are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, multiple sclerosis, cardiovascular diseases, central nervous system injury and different forms of inflammation.