2,2-Dimethyl-propionic acid 4-hydrazino-phenyl ester | 786709-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2,2-Dimethyl-propionic acid 4-hydrazino-phenyl ester
• 英文别名: (4-hydrazinylphenyl) 2,2-dimethylpropanoate
• CAS: 786709-15-7
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: XIDJDVLVPATONM-UHFFFAOYSA-N

物化性质

• 沸点：
  336.8±25.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Phosphonate linkers and their use to facilitate cellular retention of compounds
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10869929B2

  公开（公告）日：2020-12-22

  Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.

  本文介绍了膦酸盐连接体及其在将具有被动细胞渗透性的化合物输送到细胞中的用途，其中膦酸盐基团可促进化合物在细胞中的保留。
• PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS
  申请人：Garbaccio Robert M.

  公开号：US20190030171A1

  公开（公告）日：2019-01-31

  Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
• PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20210015930A1

  公开（公告）日：2021-01-21

  Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
• [EN] PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS<br/>[FR] LIEURS DE PHOSPHONATE ET LEUR UTILISATION POUR FACILITER LA RÉTENTION CELLULAIRE DE COMPOSÉS
  申请人：MERCK SHARP & DOHME

  公开号：WO2017132103A2

  公开（公告）日：2017-08-03

  Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitateS cellular retention of the compound are described.