[Ni(2-{1-[6-(1-selenosemicarbazonoethyl)-2-pyridyl]ethylidene}hydrazine carbonitrile)] | 931088-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Ni(2-{1-[6-(1-selenosemicarbazonoethyl)-2-pyridyl]ethylidene}hydrazine carbonitrile)]
• 英文别名: [Ni(hcn)]；[Ni(2-(1-[6-(1-selenosemicarbazonoethyl)-2-pyridyl]ethylidene)-hydrazine carbonitrile(-2H))]
• CAS: 931088-62-9
• 化学式: C₁₁H₁₁N₇Se*Ni
• 分子量: 378.905
• InChiKey: FCJXTYMLBMVHDR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢受体数：
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文献信息

• High antioxidative potential and low toxic effects of selenosemicarbazone metal complexes
  作者：Dragana Dekanski、Tamara Todorovic、Dragana Mitic、Nenad Filipovic、Natalija Polovic、Katarina Andjelkovic

  DOI：10.2298/jsc130315035d

  日期：——

  Novel metal-based compounds with therapeutic potential became the subject of intense investigation in inorganic chemistry and biomedical science. Recently, strong dose-dependent cytotoxic activity against several human cancer cell lines of selenosemicarbazone metal complexes was demonstrated. The aim of the present study was to investigate in vitro antioxidative potential of Ni(II), Cd(II) and Zn(II) selenosemicarbazone complexes. All three investigated complexes exhibited high ABTS radical scavenging capacity, comparable with ascorbic acid. In the acute toxicity study, administration of the compounds was performed orally to the mice at the single doses and they were observed for clinical signs, body weight effects, and mortality for 14 days after which they were sacrificed for gross organ necropsy. Body weight did not vary after administration, and the autoptic analysis failed to show appreciable macroscopic alterations of internal organs. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.

  具有治疗潜力的新型金属基化合物已成为无机化学和生物科学领域深入研究的主题。 在无机化学和生物医学领域，人们对具有治疗潜力的新型金属基化合物进行了深入研究。 最近，硒脒唑酮金属复合物对几种人类癌症细胞系具有强烈的剂量依赖性细胞毒性活性。 硒代氨基羰基金属复合物对几种人类癌细胞株具有很强的剂量依赖性细胞毒性活性。 本研究的目的是研究硒脒唑酮金属配合物的体外抗氧化潜力。 的体外抗氧化潜力。所有 硒羰基化合物都具有很高的 ABTS 自由基清除能力，可与抗坏血酸媲美、 与抗坏血酸相当。在急性毒性研究中 在急性毒性研究中，小鼠口服了单剂量的化合物，并观察了小鼠的临床症状、体重、血压和血糖。 14天，观察小鼠的临床症状、体重影响和死亡率。 14天后，对小鼠进行大体器官解剖。体重 体重在给药后没有变化，自检分析也没有显示 内脏器官发生了明显的宏观改变。总的来说 化合物表现出低毒性效应，符合进一步体内 治疗研究。
• Synthesis and characterization of Zn(II) and Cd(II) complexes with 2,6-diacetylpyridine-bis(selenosemicarbazone). Crystal structure of a Ni(II) complex with a modified 2,6-diacetylpyridine-bis(selenosemicarbazone)
  作者：Tamara R. Todorović、Alessia Bacchi、Giancarlo Pelizzi、Nenad O. Juranić、Dušan M. Sladić、Ilija D. Brčeski、Katarina K. Andelković

  DOI：10.1016/j.inoche.2006.05.011

  日期：2006.8

  A novel ligand 2,6-diacetylpyridine-bis(selenosemicarbazone) was synthesized and coordinated with Zn(II), Cd(II) and Ni(II). With Zn(II) and Cd(II), the bideprotonated ligand was coordinated as a quinquedentate in trigonal bipyramidal geometry. With Ni(II) during coordination the ligand was modified by elimination of hydrogen selenide and the product was coordinated as a quadridentate forming a square planar complex, the structure of which was determined by X-ray analysis. (C) 2006 Elsevier B.V. All rights reserved.