(S)-S-(pyrrolidin-3-yl) ethanethioate | 1112922-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-S-(pyrrolidin-3-yl) ethanethioate
• 英文别名: (3S)-3-acetylthio-pyrrolidine；S-[(3S)-pyrrolidin-3-yl] ethanethioate
• CAS: 1112922-31-2
• 化学式: C₆H₁₁NOS
• 分子量: 145.225
• InChiKey: AFYIEXRJEABQPF-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SULFONYL-SUBSTITUTED CARBAPENEM COMPOUNDS
  申请人：Huang Zhenhua

  公开号：US20110046107A1

  公开（公告）日：2011-02-24

  The present invention relates to a compound of the formula (I), pharmaceutically acceptable salts, hydrolysable esters, isomers and hydrates thereof, and hydrates of the said esters or salts, wherein R 1 , R 2 , R 3 and are as defined in the description. The present invention further relates to a process for preparing the compounds, to pharmaceutical compositions comprising the compounds, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prophylaxis of infectious diseases.

  本发明涉及式(I)的化合物、药用可接受的盐、可水解的酯、同分异构体和水合物，以及所述酯或盐的水合物，其中R1、R2、R3和R4如描述中定义。本发明进一步涉及制备这些化合物的方法、包含这些化合物的药物组合物，以及将这些化合物用于制造用于治疗和/或预防传染病的药物。
• 1-Hetero-6-/1-Hydroxyethyl/-2-SR8-1-carbadethiapen-2-EM-3-carboxylic acids
  申请人：Merck & Co., Inc.

  公开号：EP0160876A1

  公开（公告）日：1985-11-13

  Disclosed are 1-hetero-6-[1-hydroxyethyl)-2-SR8-1-carbadethiapen-2-em-3-COOR4 compounds having the structure: wherein R4 is, e.g., hydrogen, R8 is, e.g., alkyl and R9 is, e.g., halogen; the pharmaceutically acceptable salt and ester derivatives thereof and use as antibiotics. Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds.

  公开了具有以下结构的1-hetero-6-[1-羟乙基]-2-SR8-1-carbadethiapen-2-em-3-COOR4化合物：其中R4为氢等，R8为烷基等，R9为卤素等；其药学上可接受的盐和酯衍生物以及作为抗生素的用途。 还公开了制备此类化合物的工艺和包含此类化合物的药物组合物。
• 6-[1-Hydroxyethyl]-2-SR8-1-methyl-1-carba-dethiapen-2-em-3-carboxylic acids
  申请人：Merck & Co., Inc.

  公开号：EP0161541B1

  公开（公告）日：1990-12-12
• BROAD-SPECTRUM CARBAPENEMS
  申请人：VenatoRx Pharmaceuticals, Inc.

  公开号：US20210188851A1

  公开（公告）日：2021-06-24

  The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.
• US4696923A
  申请人：——

  公开号：US4696923A

  公开（公告）日：1987-09-29