amino-phenyl-acetic acid benzhydryl ester | 885613-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: amino-phenyl-acetic acid benzhydryl ester
• 英文别名: alpha-Phenylglycine, diphenylmethyl ester；benzhydryl 2-amino-2-phenylacetate
• CAS: 885613-70-7
• 化学式: C₂₁H₁₉NO₂
• 分子量: 317.387
• InChiKey: OGJKENFLIZMVQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5R)-6t-carboxymethyl-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 、 amino-phenyl-acetic acid benzhydryl ester 在 吡啶 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 (5R)-6t-{[((Ξ)-benzhydryloxycarbonyl-phenyl-methyl)-carbamoyl]-methyl}-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester
  参考文献：
  名称：

  Derivatives of 6.beta.-methylpenicillanic acid

  摘要：

  DOI：

  10.1021/jo00445a011

文献信息

• 2-(Thiocarbonylamino)acetamido-7.alpha.-methoxy cephalosporanic acid
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US03962229A1

  公开（公告）日：1976-06-08

  New 2-(thiocarbonylamino)acetamido-7.alpha.-methoxy cephalosporanic acid compounds of the following general formula, and their salts, ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(halo)lower alkyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl, furyl, thienyl or pyridyl; R.sub.2 and R.sub.4 each is hydrogen or lower alkyl; R.sub.3 is lower alkyl, phenyl or phenyl-lower alkyl; and X is hydrogen, lower alkanoyloxy or azido; are useful as antibacterial agents.

  以下是翻译的结果： 下列一般式的新2-(硫代氨基)乙酰胺基-7.alpha.-甲氧基头孢菌素酸化合物及其盐，##EQU1##其中R为氢、低烷基、苯基-低烷基、三(卤)低烷基、盐形成离子或基团##EQU2##R.sub.1为氢、低烷基、环-低烷基、不饱和环-低烷基、苯基、取代苯基、呋喃基、噻吩基或吡啶基；R.sub.2和R.sub.4各为氢或低烷基；R.sub.3为低烷基、苯基或苯基-低烷基；X为氢、低烷酰氧或叠氮基；可用作抗菌剂。
• 3-Heterothio derivatives of (.alpha.-thiocarbonylamino) cephalosporins
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US03996219A1

  公开（公告）日：1976-12-07

  3-Heterothio(.alpha.-thiocarbonylamino)cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

  3-杂硫(.alpha.-硫代氨基)头孢菌素衍生物的一般式为##STR1##其中R为氢、低碳基、苯基-低碳基、三(低碳基)硅基、三卤乙基、盐形成离子或基团##STR2##R.sub.1为氢、低碳基、环-低碳基、不饱和环-低碳基、苯基、取代苯基或噻吩基；R.sub.2和R.sub.5各为氢或低碳基；R.sub.3为五元或六元含氮、硫和/或氧的环系统；R.sub.4为低碳基、苯基或苯基-低碳基；可用作抗菌剂。
• 3-Heterothio derivatives of
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US03994889A1

  公开（公告）日：1976-11-30

  3-Heterothio(.alpha.-thiocarbonylamino)-7.alpha.-methoxycephalosporin derivatives of the general formula ##SPC1## Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##EQU1## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system, and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

  3-杂硫(.alpha.-硫代氨基)-7.alpha.-甲氧基头孢菌素衍生物的一般式为##SPC1## 其中R为氢、低碳基、苯基-低碳基、三(低碳基)硅基、三卤乙基、形成盐离子或者##EQU1## R.sub.1为氢、低碳基、环-低碳基、不饱和环-低碳基、苯基、取代苯基或噻吩基；R.sub.2 和R.sub.5各为氢或低碳基；R.sub.3为五元或六元的含氮、硫和/或氧的环系统；R.sub.4为低碳基、苯基或苯基-低碳基；可用作抗菌剂。