3R-Amino-4-(1H-imidazol-4-yl)-N-(5S-methyl4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidin-5-yl)-butyramide | 347839-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3R-Amino-4-(1H-imidazol-4-yl)-N-(5S-methyl4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidin-5-yl)-butyramide
• 英文别名: (3R)-3-amino-N-[(5S)-2-(carbamoylamino)-5-methyl-6-oxo-1,4-dihydropyrimidin-5-yl]-4-(1H-imidazol-5-yl)butanamide
• CAS: 347839-10-5
• 化学式: C₁₃H₂₀N₈O₃
• 分子量: 336.354
• InChiKey: BHVFTZSMXDBGOA-UHLUBPPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  180
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents
  申请人：Pfizer Products Inc.

  公开号：EP1113008A1

  公开（公告）日：2001-07-04

  The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, R1, R9, and R10 are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods of treating bacterial and protozoal infections in mammals by administering the above compounds.

  本发明涉及式 1 的化合物 及其药学上可接受的盐、原药和溶液，其中 Z、R1、R9 和 R10 如本文所定义。本发明还涉及含有上述化合物的药物组合物，以及通过施用上述化合物治疗哺乳动物细菌和原生动物感染的方法。
• 4-oxo-2- ureido-1,4,5,6,-tetrahydro-pyrimidine derivatives
  申请人：——

  公开号：US20020016297A1

  公开（公告）日：2002-02-07

  The present invention relates to compounds of the formula 1 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, R 1 , R 9 , and R 10 are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods of treating bacterial and protozoal infections in mammals by administering the above compounds.

  本发明涉及式 1 的化合物 1 1 及其药学上可接受的盐、原药和溶液，其中 Z、R 1 , R 9 和 R 10 如本文所定义。本发明还涉及含有上述化合物的药物组合物，以及通过施用上述化合物治疗哺乳动物细菌和原生动物感染的方法。
• 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives
  申请人：——

  公开号：US20030055053A1

  公开（公告）日：2003-03-20

  The present invention relates to compounds of the formula 1 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, R 1 , R 9 , and R 10 are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and to methods of treating bacterial and protozoal infections in mammals by administering the above compounds.

  本发明涉及式 1 的化合物 1 及其药学上可接受的盐、原药和溶液，其中 Z、R 1 , R 9 和 R 10 如本文所定义。本发明还涉及含有上述化合物的药物组合物，以及通过施用上述化合物治疗哺乳动物细菌和原生动物感染的方法。