4,4'-(4,5,6,7-Tetrabromo-1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2-iodo-6-nitrophenol)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-(4,5,6,7-Tetrabromo-1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2-iodo-6-nitrophenol)
• 英文别名: disodium;4-[3-methyl-N-(4-sulfonatobutyl)anilino]butane-1-sulfonate
• 化学式: C15H23NNa2O6S2
• 分子量: 423.5
• InChiKey: DPXDJGUFSPAFJZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.54
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  134
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Method and reagent for quantitative determination of 1,5-anhydroglucitol
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP1008657A2

  公开（公告）日：2000-06-14

  The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit useful in the method. In one embodiment, a method for the determination of 1, 5-AG is provided which comprises contacting the sample with an enzyme system which converts glucose into fructose-1,6-diphosphate and converts 1,5-AG into 1,5-AG-6-phosphate to form 1,5-AG-6-phosphate, dehydrogenating 1,5-AG-6-phosphate in the sample by the action of 1,5-AG-6-phosphate dehydrogenase in the presence of an oxidized coenzyme, and measuring the amount of the reduced coenzyme formed by the dehydrogenation reaction. A reagent and a reagent kit useful in this method are also provided.

  本发明提供了一种测定含葡萄糖样品中特定成分（如 1,5-脱水葡萄糖醇 (1,5-AG)）的简单方法，以及用于该方法的试剂和试剂盒。在一个实施方案中，提供了一种测定 1，5-AG 的方法，该方法包括将样品与酶系统接触，该酶系统将葡萄糖转化为 1，6-二磷酸果糖，并将 1，5-AG 转化为 1，5-AG-6-磷酸，形成 1、1,5-AG-6- 磷酸，在氧化辅酶存在下，通过 1,5-AG-6- 磷酸脱氢酶的作用使样品中的 1,5-AG-6- 磷酸脱氢，并测量脱氢反应形成的还原辅酶的量。此外，还提供了用于该方法的试剂和试剂盒。
• REAGENT CONTAINING PROTEASE REACTION PROMOTER AND/OR COLORANT STABILIZER
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1788081A1

  公开（公告）日：2007-05-23

  [PROBLEMS] To provide a protease reaction promoter being superior in usefulness to the known protease reaction promoters, a stabilizer for a colorant to be used in detecting an enzymatic reaction, a method therefor and a reagent and a method for measuring a glycosylated protein and the ratio of a glycosylated protein with the use of the same. [MEANS FOR SOLVING PROBLEMS] A protease reaction promoter which contains at least one member selected from among an acetate group-containing compound or its salt, N-acyltaurine or its salt and a polyoxyethylene alkyl ether sulfate or its salt; a method of promoting a protease reaction by using this protease reaction promoter, a stabilizer reagent containing cyclodextrin for stabilizing a colorant to be used in detecting an enzymatic reaction; a method of stabilization via the coexistence of cyclodextrin with the above colorant; and a reagent and a method for measuring a glycosylated protein and the ratio of a glycosylated protein with the use of the protease reaction promoter and/or the reagent containing cyclodextrin as described above.

  [问题] 提供一种在实用性上优于已知蛋白酶反应促进剂的蛋白酶反应促进剂、一种用于检测酶反应的着色剂的稳定剂、一种用于此的方法以及一种使用该促进剂和稳定剂测量糖基化蛋白质和糖基化蛋白质比率的试剂和方法。[解决问题的方法]一种蛋白酶反应促进剂，它含有至少一种选自含醋酸基的化合物或其盐、N-酰基牛磺酸或其盐和聚氧乙烯烷基醚硫酸盐或其盐中的成员；一种通过使用这种蛋白酶反应促进剂促进蛋白酶反应的方法，一种含有环糊精的稳定剂试剂，用于稳定检测酶反应中使用的着色剂；通过环糊精与上述着色剂共存进行稳定的方法；以及使用上述蛋白酶反应促进剂和/或含有环糊精的试剂测量糖基化蛋白质和糖基化蛋白质比率的试剂和方法。
• METHOD FOR MEASURING ACTIVITY OF HUMAN PANCREATIC LIPASE
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2987867A1

  公开（公告）日：2016-02-24

  A measurement method for human pancreatic lipase activity in a sample, includes a contact step of bringing a bile acid that makes a pH for giving a maximum value of human pancreatic lipase activity to be lower than 7.7, a diglyceride and a colipase into contact with the sample at pH 7.4 or lower; and a detection step of detecting a signal amount varying in accordance with the human pancreatic lipase activity in the sample, and the bile acid is a bile acid containing: one of or two or more of a-type bile acids selected from the group consisting of GDCA, GCDCA, TDCA, TCDCA and salts thereof; and/or a combination of one of or two or more of b-1-type bile acids selected from the group consisting of GCA, GUDCA, TCA, TUDCA and salts thereof, and one of or two or more of b-2-type bile acids selected from the group consisting of DCA, CDCA and salts thereof.

  一种样品中人胰脂肪酶活性的测量方法，包括以下接触步骤：将使人胰脂肪酶活性最大值的 pH 值低于 7.7 的胆汁酸、二甘油酯和胶质酶与 pH 值为 7.检测步骤是检测随样品中人胰脂肪酶活性变化而变化的信号量，胆汁酸是一种胆汁酸，其中含有选自 GDCA、GCDCA、TDCA、TCDCA 及其盐类的 a 型胆汁酸中的一种或两种以上；和/或选自 GCA、GUDCA、TCA、TUDCA 及其盐类的 b-1 型胆汁酸中的一种或两种以上，以及选自 DCA、CDCA 及其盐类的 b-2 型胆汁酸中的一种或两种以上的组合。
• MEASUREMENT OF GLYCOPROTEIN
  申请人：ARKRAY, Inc.

  公开号：EP3461907A1

  公开（公告）日：2019-04-03

  Provided is a method for measuring a glycoprotein using an enzymatic method, and the method includes simplified steps. In one aspect, the present invention relates to a method for measuring a glycoprotein in a sample, the measurement method including (1) to (3) below. In this measurement method, a single reagent is mixed with a sample in order to perform (2) and (3) below. (1) Denaturing a protein in the sample. (2) Reacting a glycoprotein in the sample with amadoriase to allow a colour forming agent to produce a colour. (3) Measuring the developed colour signal of the sample after (1) and (2), and calculating the glycoprotein level.

  本发明提供了一种利用酶法测量糖蛋白的方法，该方法包括简化步骤。 一方面，本发明涉及一种测量样品中糖蛋白的方法，该测量方法包括以下（1）至（3）。在该测量方法中，将单一试剂与样品混合，以执行以下(2)和(3)。 (1) 将样品中的蛋白质变性。 (2) 将样品中的糖蛋白与氨甲蝶呤酶反应，使显色剂产生颜色。 (3) 测量(1)和(2)后样品的显色信号，并计算糖蛋白的含量。
• Measurement method for human pancreatic lipase activity
  申请人：ASAHI KASEI PHARMA CORPORATION

  公开号：US10000791B2

  公开（公告）日：2018-06-19

  A measurement method for human pancreatic lipase activity in a sample, includes bringing a bile acid that makes a pH for giving a maximum value of human pancreatic lipase activity to be lower than 7.7, a diglyceride and a colipase into contact with the sample at pH 7.4 or lower; and detecting a signal amount varying in accordance with the human pancreatic lipase activity in the sample, and the bile acid is a bile acid containing: one of or two or more of a-type bile acids selected from the group consisting of GDCA, GCDCA, TDCA, TCDCA and salts thereof; and/or a combination of one of or two or more of b-1-type bile acids selected from the group consisting of GCA, GUDCA, TCA, TUDCA and salts thereof, and one of or two or more of b-2-type bile acids selected from the group consisting of DCA, CDCA and salts thereof.

  一种样品中人胰脂肪酶活性的测量方法，包括将使人胰脂肪酶活性最大值的 pH 值低于 7.7 的胆汁酸、二甘油酯和胶质酶与 pH 值为 7.4或更低的pH值与样品接触；并检测随样品中人胰脂肪酶活性变化而变化的信号量，胆汁酸是一种胆汁酸，其中含有选自 GDCA、GCDCA、TDCA、TCDCA 及其盐类的 a 型胆汁酸中的一种或两种以上；和/或选自 GCA、GUDCA、TCA、TUDCA 及其盐类的 b-1 型胆汁酸中的一种或两种以上，以及选自 DCA、CDCA 及其盐类的 b-2 型胆汁酸中的一种或两种以上的组合。