4,7-二氯-异吲哚-1,3-二酮 | 55789-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 4,7-二氯-异吲哚-1,3-二酮
• 英文名称: 4,7-dichloro-isoindole-1,3-dione
• 英文别名: 3,6-dichlorophthalimide；4,7-dichloro-isoindoline-1,3-dione；4,7-Dichlor-isoindolin-1,3-dion；4,7-Dichloroisoindoline-1,3-dione；4,7-dichloroisoindole-1,3-dione
• CAS: 55789-50-9
• 化学式: C₈H₃Cl₂NO₂
• 分子量: 216.023
• InChiKey: BIXWQKYACRKUFW-UHFFFAOYSA-N

物化性质

• 密度：
  1.643±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,7-二氯-异吲哚-1,3-二酮 在 乙醇 、 一水合肼 作用下， 生成 2-amino-4,7-dichloro-isoindoline-1,3-dione
  参考文献：
  名称：

  Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability

  摘要：

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.

  DOI：

  10.1093/geronb/56.4.s206
• 作为产物：
  描述：

  3,6-二氯苯二甲酸酐 在 氨 作用下， 生成 4,7-二氯-异吲哚-1,3-二酮
  参考文献：
  名称：

  Graebe; Gourevitz, Chemische Berichte, 1900, vol. 33, p. 2024

  摘要：

  DOI：

文献信息

• Substituted Dihydroisoindolones As Allosteric Modulators of Glucokinase
  申请人：Dudash Joseph

  公开号：US20070099930A1

  公开（公告）日：2007-05-03

  The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.

  本发明涉及式(I)的化合物，制备这些化合物的方法，组合物，中间体和衍生物，以及用于治疗葡萄糖激酶介导的疾病。更具体地说，本发明的化合物是葡萄糖激酶调节剂，可用于治疗包括但不限于II型糖尿病在内的疾病。
• [EN] PHTHALOCYANINES AND THEIR USE IN INK-JET PRINTING<br/>[FR] PHTALOCYANINES ET LEUR UTILISATION EN IMPRESSION PAR JET D'ENCRE
  申请人：FUJIFILM IMAGING COLORANTS LTD

  公开号：WO2010146381A1

  公开（公告）日：2010-12-23

  A process for preparing a mixture of phthalocyanine or metallo-phthalocyanine dyes and salts thereof which comprises cyclisation of a compound of Formula (1) with a compound of Formula (2) and/or Formula (3): wherein: R1 is a hydrocarbyl group; R2 is H or a hydrocarbyl group;10 R3 is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted heterocyclyl; R4 and R5 are cyano, carboxy carboxamide or together form a group of formula (a); X is an electron withdrawing group;and n is 1 to 4: wherein the cyclisation process is carried out in the presence of a suitable nitrogen source (if required) and a metal salt (if required). Also novel compounds, inks, printing processes, printed materials(including color filters)and ink jet cartridges.

  一种制备邻苯二甲酰亚菲青或金属邻苯二甲酰亚菲青染料及其盐的混合物的方法，包括将化合物式（1）与化合物式（2）和/或化合物式（3）环化：其中：R1是烃基团；R2是H或烃基团；R3是H，可选择地取代的烷基，可选择地取代的芳基或可选择地取代的杂环烷基；R4和R5是氰基，羧基，羧酰胺基或共同形成式（a）的基团；X是电子吸引基团；n为1至4：其中环化过程在适当的氮源（如果需要）和金属盐（如果需要）的存在下进行。此外，还涉及新化合物、墨水、印刷工艺、印刷材料（包括彩色滤光片）和喷墨墨盒。
• Investigation of the Thionation Reaction of Cyclic Imides
  作者：A. Orzeszko、J. K. Maurin、D. Melon-Ksyta

  DOI：10.1515/znb-2001-1012

  日期：2001.10.1

  A series of monothioimides and dithioimides were synthesised using Lawesson’s reagent. It has been found that two main effects affect thionation reaction. The high polarity of carbonyl groups leads to good yields of mono- and dithioimides. On the other hand, steric hindrance in the vicinity of the carbonyl group strongly inhibits the replacement of the oxygen atom by sulfur.

  使用Lawesson试剂合成了一系列单硫代亚胺和二硫代亚胺。发现两个主要因素影响了硫化反应。羰基团的高极性导致了单硫代亚胺和二硫代亚胺的高产率。另一方面，在羰基团附近的立体位阻强烈抑制了氧原子被硫取代。
• Novel substituted diamine derivatives useful as motilin antagonists
  申请人：——

  公开号：US20020013352A1

  公开（公告）日：2002-01-31

  The present invention relates to novel substituted diamine derivatives for the formula 1 wherein R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , A, Y and n are as described in the specification, pharmaceutical compositions containing them and intermediates used in their manufacture. More particularly, the compounds of the invention are motilin receptor antagonists useful for the treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome.

  本发明涉及一种新型的取代二胺衍生物，其化学式为1，其中R1、R2、R3、R4、X1、X2、X3、X4、A、Y和n如说明书中所述，包含它们的药物组合物以及用于它们制造的中间体。更具体地说，本发明的化合物是莫替林受体拮抗剂，可用于治疗相关疾病和疾病，如胃食管反流疾病、导致肥胖的进食障碍和肠易激综合征。
• Novel substituted diamine derivatives useful as motlin antagonists
  申请人：——

  公开号：US20030203906A1

  公开（公告）日：2003-10-30

  The present invention relates to novel substituted diamine derivatives for the formula 1 wherein R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , A, Y and n are as described in the specification, pharmaceutical compositions containing them and intermediates used in their manufacture. More particularly, the compounds of the invention are motilin receptor antagonists useful for the treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome.

  本发明涉及一种新的取代二胺衍生物，其化学式为1，其中R1、R2、R3、R4、X1、X2、X3、X4、A、Y和n如规范中所述，以及含有它们的制药组合物和用于制造它们的中间体。更具体地说，本发明的化合物是胃动素受体拮抗剂，可用于治疗相关疾病和疾病，例如胃食管反流病、导致肥胖的进食障碍和肠易激综合征。