{5-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide | 1370652-57-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {5-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide
• 英文别名: 6-amino-5-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-(1-methyl-6-oxopyridin-3-yl)pyridazine-3-carboxamide
• CAS: 1370652-57-5
• 化学式: C₁₉H₁₆Cl₂FN₅O₃
• 分子量: 452.272
• InChiKey: CAHIYUNFMZWRQZ-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
  申请人：Liang Congxin

  公开号：US20130203763A1

  公开（公告）日：2013-08-08

  The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
• US9242958B2
  申请人：——

  公开号：US9242958B2

  公开（公告）日：2016-01-26