2-(Propyn-3-yloxy)-4-(pyrrolidin-1-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-5-carboxamide | 452097-21-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Propyn-3-yloxy)-4-(pyrrolidin-1-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-5-carboxamide
• 英文别名: 2-prop-2-ynoxy-4-pyrrolidin-1-yl-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-5-carboxamide
• CAS: 452097-21-1
• 化学式: C₂₀H₁₉F₃N₄O₂
• 分子量: 404.392
• InChiKey: AMDKSEACYBPYOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators
  申请人：——

  公开号：US20020183335A1

  公开（公告）日：2002-12-05

  There is provided a method of treatment for disorders responsive to the modulation of KCNQ potassium channels by administering to a mammal in need thereof a therapeutically effective amount of a 2,4-disubstituted pyrimidine-5-carboxamide derivative of the Formula I 1 wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined below. The present invention also provides pharmaceutical compositions comprising openers or activators of the KCNQ potassium channels and especially to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine.

  提供了一种治疗对KCNQ钾通道调节敏感的疾病的方法，包括向需要治疗的哺乳动物中投与治疗有效量的公式I1的2,4-二取代嘧啶-5-羧酰胺衍生物，其中R1、R2、R3、R4和R5如下定义。本发明还提供了包含KCNQ钾通道开放剂或激活剂的制药组合物，特别是针对对KCNQ钾通道开放活性敏感的疾病的治疗方法，如偏头痛。