2-Propanamine, 1-([1,1'-biphenyl]-4-yloxy)- | 883515-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Propanamine, 1-([1,1'-biphenyl]-4-yloxy)-
• 英文别名: 1-(4-phenylphenoxy)propan-2-amine
• CAS: 883515-67-1
• 化学式: C₁₅H₁₇NO
• mdl: MFCD06246002
• 分子量: 227.3
• InChiKey: ZKZMPUKMZBXSHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• DIPHENYLOXYALKYLAMINE DERIVATIVES AND ARYLOXYALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE OF SAID PHARMACEUTICAL COMPOSITION FOR TREATING, PREVENTING OR INHIBITING CHRONIC PULMONARY INFLAMMATORY DISEASES AND METHOD FOR TREATING OR PREVENTING SUCH DISEASES
  申请人：FUNDACAO OSWALDO CRUZ

  公开号：US20160214926A1

  公开（公告）日：2016-07-28

  The present invention relates to diphenyloxyalkylamine derivatives and aryloxyalkylamine derivatives that are structurally analogous to mexiletine, said derivatives having important biological activity and not causing the undesired side effects observed with the prototype, as well as with other drugs from the same therapeutic class as the prototype. The derivatives of the present invention have formulas II and III and are used for treating, preventing or inhibiting pulmonary inflammatory diseases, for example, asthma and chronic obstructive pulmonary disease (COPD).

  本发明涉及与美西律林结构类似的二苯氧基烷基胺衍生物和芳氧基烷基胺衍生物，这些衍生物具有重要的生物活性，并且不会引起原型药物以及与原型药物同一治疗类别的其他药物所观察到的不良副作用。本发明的衍生物具有II和III式，并用于治疗、预防或抑制肺部炎症性疾病，例如哮喘和慢性阻塞性肺疾病（COPD）。