1-benzo[1,3]dioxol-5-yl-3-(2-phenoxy-acetyl)-thiourea | 698978-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1-benzo[1,3]dioxol-5-yl-3-(2-phenoxy-acetyl)-thiourea
• 英文别名: N-(1,3-benzodioxol-5-ylcarbamothioyl)-2-phenoxyacetamide
• CAS: 698978-89-1
• 化学式: C₁₆H₁₄N₂O₄S
• 分子量: 330.364
• InChiKey: DRWMVMBBESPDTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted aryl thioureas and related compounds; inhibitors of viral replication
  申请人：Chen Dawei

  公开号：US20060014836A1

  公开（公告）日：2006-01-19

  The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

  本发明提供了公式I的化合物和药物可接受的盐，其中变量A1、A2、R1、R2、V、W、X、Y和Z的定义在此处。本文所描述的公式I的某些化合物具有强大的抗病毒活性。本发明特别提供了公式I的化合物，这些化合物是强效和/或选择性的丙型肝炎病毒复制抑制剂。本发明还提供了含有一个或多个公式I的化合物、或这些化合物的盐、溶剂或酰化前药物以及一个或多个药学可接受的载体、赋形剂或稀释剂的制药组合物。本发明还包括通过向这些患者投予有效减少疾病或疾病症状的公式I化合物量来治疗某些传染病患者的方法。这些传染病包括病毒感染，特别是丙型肝炎病毒感染。本发明特别包括治疗人类患者感染病的方法，但也包括治疗其他动物，包括家畜和驯养的伴侣动物感染病的方法。治疗方法包括单独使用公式I的化合物作为活性剂或与一个或多个其他治疗剂联合使用公式I的化合物。
• US7094807B2
  申请人：——

  公开号：US7094807B2

  公开（公告）日：2006-08-22
• US7476686B2
  申请人：——

  公开号：US7476686B2

  公开（公告）日：2009-01-13