nicotinoyloxymethyl (4-nitrophenyl)carbonate | 101623-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: nicotinoyloxymethyl (4-nitrophenyl)carbonate
• 英文别名: (4-Nitrophenoxy)carbonyloxymethyl pyridine-3-carboxylate
• CAS: 101623-73-8
• 化学式: C₁₄H₁₀N₂O₇
• 分子量: 318.243
• InChiKey: HUMGZTWPOWZUHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• A new process for preparing novel N-(acyloxy-alkoxy) carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
  申请人：Merck & Co., Inc.

  公开号：EP0167451A2

  公开（公告）日：1986-01-08

  This invention relates to a new one-step process for preparation of novel N-(acyloxy-alkoxy) carbonyl derivatives useful as bioreversible prodrug moieties for drugs having a primary or secondary amine function thereon.

  本发明涉及一种一步法制备新型 N-（酰氧基-烷氧基）羰基衍生物的新工艺，该衍生物可用作具有伯胺或仲胺功能的药物的生物可逆原药分子。
• TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0790247A1

  公开（公告）日：1997-08-20

  The present invention relates to a tetrahydroisoquinoline derivative represented by the following formula 1 exhibiting an inhibitory action for agglutination caused by fibrinogen, which may be effectively used as an antithrombotic agent or a platelet agglutination-inhibiting agent. The present invention also relates to a medical preparation containing such compound. In formula 1, B and G are an alkylene optionally substituted with an alkyl or the like; D is H, an alkyl, or the like; E is 1,2,3,4-tetrahydroisoquinoline optionally substituted with R1 to R4 which binds to G at position 2; R1 to R4 are an alkyl or the like; L is hydroxy or the like; and A is a substituent represented by formula (2), and C is carbon. In formula 2, M and R5 to R8 are H, an alkyl or the like.

  本发明涉及一种由下式 1 表示的四氢异喹啉衍生物，该衍生物对纤维蛋白原引起的凝集具有抑制作用，可有效用作抗血栓剂或血小板凝集抑制剂。本发明还涉及一种含有此类化合物的医疗制剂。 在式 1 中，B 和 G 是任选被烷基或类似物取代的亚烷基；D 是 H、烷基或类似物；E 是任选被 R1 至 R4 取代的 1，2，3，4-四氢异喹啉，它在第 2 位与 G 结合；R1 至 R4 是烷基或类似物；L 是羟基或类似物；A 是式 (2) 所代表的取代基，C 是碳。 在式 2 中，M 和 R5 至 R8 是 H、烷基或类似物。
• N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF
  申请人：UBE INDUSTRIES LIMITED

  公开号：EP1020467A1

  公开（公告）日：2000-07-19

  The present invention discloses the compound represented by the formula (I): wherein A represents the following formula (a-1) or the following formula (a-2): B represents the following formula (b): (wherein the symbols are each as defined in the specification) or a pharmaceutically acceptable salts thereof, and intermediates for the preparation thereof, which have excellent platelet aggregation inhibitory activity and other properties and useful as prophylactic or therapeutic agents for diseases associated with a fibrinogen receptor, thrombosis, infarction and the like.

  本发明公开了式 (I) 所代表的化合物： 其中 A 代表下式（a-1）或下式（a-2）： B 代表下式（b）： (其中各符号如说明书中所定义）或其药学上可接受的盐类，以及用于制备它们的中间体，它们具有优异的血小板聚集抑制活性和其他特性，可用作与纤维蛋白原受体、血栓形成、梗塞等相关疾病的预防或治疗药物。
• 2-PEPERAZINONE-1-ACETIC ACID DERIVATIVES AND THEIR USE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0970071A1

  公开（公告）日：2000-01-12
• US4916230A
  申请人：——

  公开号：US4916230A

  公开（公告）日：1990-04-10