N-[2-[(4-aminopyrimidin-5-yl)amino]ethyl]-2,2-dimethyl-4-oxo-1,3-benzodioxine-6-carboxamide | 1401529-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: N-[2-[(4-aminopyrimidin-5-yl)amino]ethyl]-2,2-dimethyl-4-oxo-1,3-benzodioxine-6-carboxamide
• CAS: 1401529-46-1
• 化学式: C₁₇H₁₉N₅O₄
• 分子量: 357.369
• InChiKey: YZRJKSVFWGLBBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：CHO Young Lag

  公开号：US20120264727A1

  公开（公告）日：2012-10-18

  The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R 1 , and R 2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

  本发明涉及由化学公式1表示的新型头孢菌素衍生物。其中，X、Y、L、R1和R2与发明描述中定义的相同。本发明还涉及包含由化学公式1表示的新型头孢菌素衍生物、前药、水合物、溶剂化物、异构体或药用可接受盐作为有效成分的药物抗生素组合物。根据本发明，新型头孢菌素衍生物、前药、水合物、溶剂化物、异构体或药用可接受盐作为广谱抗生素耐药、低毒性的有效成分，特别是在革兰氏阴性细菌中，可以具有强大的抗菌活性。
• NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：LegoChem Biosciences, Inc.

  公开号：EP2706062A2

  公开（公告）日：2014-03-12

  The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

  本发明涉及化学式 1 所代表的新型头孢菌素衍生物。 其中，X、Y、L、R1 和 R2 与本发明描述中所定义的相同。 本发明还涉及药物抗生素组合物，该组合物包含化学式 1 所代表的新型头孢菌素衍生物、其原药、其水合物、其溶液、其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物、其原药、其水合物、其溶物、其异构体或其药学上可接受的盐作为有效成分，可用于广谱抗抗生素、低毒性，特别是革兰氏阴性菌，具有很强的抗菌活性。
• US8329684B2
  申请人：——

  公开号：US8329684B2

  公开（公告）日：2012-12-11
• US9630977B2
  申请人：——

  公开号：US9630977B2

  公开（公告）日：2017-04-25
• [EN] NOVEL CEPHALOSPORIN DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME<br/>[FR] NOUVEAU DÉRIVÉ DE CÉPHALOSPORINE ET COMPOSITION MÉDICALE LE CONTENANT
  申请人：LEGOCHEM BIOSCIENCES LTD

  公开号：WO2012134184A2

  公开（公告）日：2012-10-04

  본 발명은 명세서 상의 화학식 1로 표시되는 신규한 세파로스포린 유도체에 관한 것이다. 화학식 1에서, X, Y, L, R1, R2 는 발명의 상세한 설명에 정의된 바와 동일하다. 또한, 본 발명은 상기 화학식 1의 신규한 세파로스포린 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염을 유효성분으로 함유하는 항생제용 의약 조성물에 관한 것이다. 본 발명에 따른 신규한 세파로스포린 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염은 내성균에 대한 항균 스펙트럼이 넓고, 독성이 낮으며, 특히 그람음성균에 강한 항균효과를 나타내므로, 항생제로 유용하게 사용될 수 있다.