4-(4-benzyl-5-phenyl-4,5-dihydrooxazol-2-yl)-N,N-dimethylaniline | 1429616-07-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(4-benzyl-5-phenyl-4,5-dihydrooxazol-2-yl)-N,N-dimethylaniline
• CAS: 1429616-07-8
• 化学式: C₂₄H₂₄N₂O
• 分子量: 356.467
• InChiKey: AVIVKRNDEUDGOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  24.83
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 、 nickel(II) chloride hexahydrate 、 四氯化钛 、 1-丙基磷酸酐 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 反应 3.5h， 生成 4-(4-benzyl-5-phenyl-4,5-dihydrooxazol-2-yl)-N,N-dimethylaniline
  参考文献：
  名称：

  Acid controlled generation of indanes and oxazolines from β-hydroxyarylethanamide

  摘要：

  Simple and efficient protocols for the construction of substituted indanes and oxazolines through intramolecular cyclization of beta-hydroxyarylethanamide using trifluoromethanesulfonic acid and titanium tetrachloride in 1,2-dichloroethane respectively have been described. The selectivity due to different acid catalysts was explored and optimized to achieve good to excellent yield. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.02.033

文献信息

• Synthesis of Isoquinoline Derivatives from <font>β</font>-Hydroxyarylethanamides
  作者：Rajendran Suresh、Shanmugam Muthusubramanian

  DOI：10.1080/00397911.2015.1042590

  日期：2015.7.18

  A simple and efficient protocol for the construction of medicinally important substituted isoquinolines through intramolecular cyclization of -hydroxyarylethanamides using acetic anhydride and phosphorous pentoxide in dioxane has been described. The chemo- and regioselectivities due to the influence of different catalysts were investigated and optimized for good to excellent yields. All the synthesized compounds have been characterized by NMR and mass spectral analyses.