4-[2-(2-furyl)vinyl]-2-imino-5,5-dimethyl-2,5-dihydrofuran-3-carboxamide hydrochloride | 1202751-65-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 4-[2-(2-furyl)vinyl]-2-imino-5,5-dimethyl-2,5-dihydrofuran-3-carboxamide hydrochloride
• 英文别名: 4-[2-(2-Furyl)vinyl]-2-imino-5,5-dimethyl-2,5-di-hydrofuran-3-carboxamide hydrochloride；4-[2-(furan-2-yl)ethenyl]-2-imino-5,5-dimethylfuran-3-carboxamide;hydrochloride
• CAS: 1202751-65-2
• 化学式: C₁₃H₁₄N₂O₃*ClH
• 分子量: 282.727
• InChiKey: DFIXPESQAIONAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.28
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[2-(2-furyl)vinyl]-2-imino-5,5-dimethyl-2,5-dihydrofuran-3-carboxamide hydrochloride 在 水 作用下， 反应 2.0h， 生成 4-[2-(2-furyl)vinyl]-5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxamide
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082
• 作为产物：
  描述：

  4-[2-(2-furyl)vinyl]-2-imino-5,5-dimethyl-2,5-dihydrofuran-3-carboxamide 在 盐酸 作用下， 以 苯 为溶剂， 以96%的产率得到4-[2-(2-furyl)vinyl]-2-imino-5,5-dimethyl-2,5-dihydrofuran-3-carboxamide hydrochloride
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082