6-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazine-1-carbonyl}-7-methyl-1,5-diphenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione | 1259051-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazine-1-carbonyl}-7-methyl-1,5-diphenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione
• 英文别名: 6-[4-[Bis(4-fluorophenyl)methyl]piperazine-1-carbonyl]-7-methyl-1,5-diphenylpyrido[2,3-d]pyrimidine-2,4-dione
• CAS: 1259051-90-5
• 化学式: C₃₈H₃₁F₂N₅O₃
• 分子量: 643.693
• InChiKey: OVJLOAQDLXNJBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  48
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis
  申请人：Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

  公开号：EP2266984A1

  公开（公告）日：2010-12-29

  Compounds according to the general formula (I) their solvates, hydrates, esters and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

  化合物按照一般公式（I）及其溶剂化物、水合物、酯和药学上可接受的盐，用于调节Wnt信号通路活性以及用作药物，优选用于治疗癌症。
• [EN] PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS<br/>[FR] PYRIDO[2,3-D]PYRIMIDINES COMME ANTAGONISTES DE WNT POUR LE TRAITEMENT D'UN CANCER ET DE L'ARTHRITE
  申请人：DEUTSCHES KREBSFORSCH

  公开号：WO2010149786A1

  公开（公告）日：2010-12-29

  Compounds according to the general formula (I) their solvates, hydrates, esters and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.