(R)-3-(3-Amino-pyridin-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester | 1286208-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (R)-3-(3-Amino-pyridin-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
• 英文别名: (R)-tert-Butyl 3-(3-aminopyridin-2-yloxy)pyrrolidine-1-carboxylate；tert-butyl (3R)-3-(3-aminopyridin-2-yl)oxypyrrolidine-1-carboxylate
• CAS: 1286208-47-6
• 化学式: C₁₄H₂₁N₃O₃
• 分子量: 279.339
• InChiKey: YNAALYNGYTZCOK-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  77.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] 3-IMIDAZOLYL-INDOLES POUR TRAITER LES MALADIES PROLIFÉRATIVES
  申请人：NOVARTIS AG

  公开号：WO2012176123A1

  公开（公告）日：2012-12-27

  The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I), in which: R1, R2, R3 and R4 are as defined in the Summary of the Invention. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.