Magnoflorin | 13074-53-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: Magnoflorin
• 英文别名: magnoflorine；(+)-Magnoflorine Iodide；2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-1,11-diol
• CAS: 13074-53-8
• 化学式: C₂₀H₂₄NO₄
• 分子量: 342.415
• InChiKey: YLRXAIKMLINXQY-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SINOMENINE DERIVATIVES, SYNTHETIC METHODS AND USES THEREOF
  申请人：Yao Zhujun

  公开号：US20120308589A1

  公开（公告）日：2012-12-06

  The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).

  该发明涉及青藤碱衍生物，其合成方法及应用。青藤碱衍生物包括氧化衍生物和C-10取代的青藤碱衍生物。基于青藤碱结构上易氧化的酚基团，可以利用氧化、氧化去芳香化或共轭加成芳香化来引入C-10取代基以合成青藤碱衍生物。该发明的青藤碱衍生物具有以下结构：通过体外TNF-α抑制实验，评估了合成化合物的活性。这些实验结果表明，大多数化合物具有抗炎作用，有些化合物的活性优于青藤碱。这些化合物可用于治疗类风湿性关节炎等免疫性疾病。
• [EN] SINOMENINE AND SINOMENINE COMPOUNDS, SYNTHESIS AND USE<br/>[FR] SINOMENINE ET COMPOSES DE SINOMENINE, PROCEDE DE SYNTHESE ASSOCIE ET UTILISATION ASSOCIEE
  申请人：SHANGHAI INST MATERIA MEDICA

  公开号：WO2004048340A1

  公开（公告）日：2004-06-10

  The invention relates to sinomenine and compounds thereof and also to compounds of formula (I), wherein R1 represents an alkyl group; R2 represents a hydrogen atom or an alkylcarbonyl group, an haloalkylcarbonyl group or an arylcarbonyl; Y represents a group (II), (III) or (IV); R3 ,R4, R’4, R5, R’5 and R6 are as defined in the description; and X represents a halogen atom. Medicaments.

  这项发明涉及青藤碱及其化合物，以及化合物的公式（I），其中R1代表烷基基团；R2代表氢原子或烷基羰基基团、卤代烷基羰基基团或芳基羰基；Y代表群（II）、（III）或（IV）；R3、R4、R’4、R5、R’5和R6如描述中所定义；X代表卤素原子。药物。
• Anti-inflammatory effects of the partially purified extract of radix stephaniae tetrandrae
  申请人：TCM Biotech International CORP.

  公开号：US20040105907A1

  公开（公告）日：2004-06-03

  This invention relates to inflammatory responses in isolated peripheral human neutrophils that studied in the presence or absence of specially processed Radix Stephaniae tetrandrae (SPRST). We conclude that SPRST exerts anti-inflammatory effects by interfering with reactive oxygen species (ROS) production and calcium (Ca 2+ ) influx through G-protein modulation to prevent Mac-1 up-regulation and firm adhesion by neutrophils during activation.Thns, SPRST may be clinical beneficial in the prevention of cardiovascular disease, or other diseases related to over activation of neutrophil.

  本发明涉及在孤立的外周人类中性粒细胞中研究炎症反应，其在有或无经过特殊处理的四棱防风（SPRST）的情况下进行。我们得出结论，SPRST通过干扰反应性氧化物（ROS）的产生和钙（Ca2+）通量通过G蛋白调节来发挥抗炎作用，以防止激活期间中性粒细胞的Mac-1上调和牢固粘附。因此，SPRST在预防心血管疾病或其他与中性粒细胞过度激活有关的疾病方面可能具有临床益处。
• POLYSACCHARIDE PS-A ISOLATED FROM THE PLANT OF GENUS EPIMEDIUM VIOLACEUM MORR. ET DECNE., PROCESS FOR ITS PREPARATION, AND INFECTION-PREVENTING AGENT AND IMMUNOSTIMULATING AGENT CONTAINING THE POLYSACCHARIDE AS EFFECTIVE INGREDIENT
  申请人：ZENYAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0086233A1

  公开（公告）日：1983-08-24

  Polysaccharide PS-A isolated from the plant of genus Epimedium violaceum Morr. et decne. having the following properties, process for its preparation, and an infection- preventing agent and an immunostimulating agent containing same as an effective ingredient: 1. Elemental analysis: C = 40,92, H = 6.17, ash = trace; 2. Molecular Weight: 75,000 + 25,000 (mean molecular weight); 3. Decomposition point: 205°C; 4. pH: 7.0 (100 mg of PS-A in 50 ml of water); 5. Specific rotary power: [α]19 = -23.6°C (in H2O,c = 0.527); 6. IR absorption spectrum: v KBr max (cm-1): 3400, 2900, 1620, 1400, 1230, 1060; 7. UV absorption spectrum: no maximum absorptions in 240 to 400 nm; 8. Appearance: white to slightly brown amorphous powder; 9. Solubility: soluble in water, insoluble in methanol, ethanol, acetone, ethyl, acetat, diethyl ether, hexane, and chloroform; 10. Color reaction: positive for the following reactions: (a) anthrone test, (b) Molisch reaction, (c) skatole reaction, (d) Bial reaction; negative for the following reactions: (a) ninhydrin reaction, (b) 2,4-DNP reaction, (c) Selivanoff reaction, (d) naphthoresorcin reaction, (e) carbazole reaction; 11. Constitutive sugar: arabinose and galactose; 12. Uniformity, uniform in ultracentrifugation, electrophoresis, and gel filtration.

  从 Epimedium violaceum Morr. et decne.属植物中分离出的多糖 PS-A，具有以下特性，其制备方法，以及含有该多糖作为有效成分的预防感染剂和免疫刺激剂： 1.元素分析：C=40.92，H=6.17，灰分=痕量； 2. 分子量：75,000 + 25,000（平均分子量）； 3. 分解点：205°C； 4. pH 值：7.0（100 毫克 PS-A 在 50 毫升水中）； 5. 比旋光度：[α]19 = -23.6°C （在 H2O 中，c = 0.527）； 6. 红外吸收光谱：v KBr max (cm-1)：3400, 2900, 1620, 1400, 1230, 1060； 7. 紫外吸收光谱：在 240 至 400 纳米波长范围内无最大吸收； 8. 外观：白色至微棕色无定形粉末； 9. 溶解性：溶于水，不溶于甲醇、乙醇、丙酮、乙醇、乙醚、己烷和氯仿； 10.颜色反应：对下列反应呈阳性：(a) anthrone test，(b) Molisch reaction，(c) skatole reaction，(d) Bial reaction；对下列反应呈阴性：(a) ninhydrin reaction，(b) 2,4-DNP reaction，(c) Selivanoff reaction，(d) naphthoresorcin reaction，(e) carbazole reaction； 11.组成糖：阿拉伯糖和半乳糖； 12. 均匀性，在超速离心、电泳和凝胶过滤中均匀。
• Ophthalmic compositions
  申请人：HOUSTON BIOTECHNOLOGY INCORPORATED

  公开号：EP0257887A2

  公开（公告）日：1988-03-02

  Alkaloids, chalcone derivatives, and fused benzo-oxaheterocycles are employed for improvement in ocular blood flow. The compounds can be administered topically or systemically to enhance the retinal and/or choroidal blood flow without having any adverse affect on the cardiovascular system.

  生物碱、查尔酮衍生物和融合的苯并氧杂环化合物可用于改善眼部血流量。 这些化合物可局部或全身给药，以增强视网膜和/或脉络膜的血流量，而不会对心血管系统产生任何不利影响。