6-methyl-biphenyl-2-carboxylic acid chloride | 854235-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-methyl-biphenyl-2-carboxylic acid chloride
• 英文别名: 6-Methylbiphenyl-2-carboxylic acid chloride；3-methyl-2-phenylbenzoyl chloride
• CAS: 854235-79-3
• 化学式: C₁₄H₁₁ClO
• 分子量: 230.694
• InChiKey: VKZPBPGDQXNMHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-methyl-biphenyl-2-carboxylic acid chloride 、 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-amino-benzoic acid amide 在 三乙胺 作用下， 以 N-甲基乙酰胺 为溶剂， 以24%的产率得到N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-(6-methylbiphenyl-2-carbonylamino)-benzoic acid amide
  参考文献：
  名称：

  Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments

  摘要：

  本发明涉及一般式1的取代哌嗪衍生物，其中R1至R7在此处定义，其异构体和盐，特别是其生理上可接受的盐，这些盐是微粒体三酰甘油转移蛋白（MTP）的有价值的抑制剂，含有这些化合物的药物以及它们的用途，以及其制备。

  公开号：

  US20020032238A1

文献信息

• AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR
  申请人：G.D. SEARLE & CO.

  公开号：EP1183239A1

  公开（公告）日：2002-03-06
• [EN] AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR<br/>[FR] ACIDE HYDROXAMIQUE A SULFONE AROMATIQUE INHIBITEUR DE METALLOPROTEASES
  申请人：SEARLE & CO

  公开号：WO2000069821A1

  公开（公告）日：2000-11-23

  A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor. A contemplated compound corresponds in structure to formula (B).