雷西纳德杂质L | 1158970-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 雷西纳德杂质L
• 英文名称: 2-(5-bromo-4-(4-methaneylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ethanoic acid
• 英文别名: 2-(5-bromo-4-(4-methylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ethanoic acid；2-(5-bromo-4-(4-methylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid；Lesinurad Impurity 8；2-[[5-bromo-4-(4-methylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
• CAS: 1158970-49-0
• 化学式: C₁₅H₁₂BrN₃O₂S
• 分子量: 378.249
• InChiKey: PDCLZQFKIFSJBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
  申请人：QUART Barry D.

  公开号：US20090197825A1

  公开（公告）日：2009-08-06

  Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

  本文描述了一些有用的化合物，可以调节血尿酸水平，包含它们的制剂和使用它们的方法。在某些实施例中，所述的化合物用于治疗或预防与尿酸异常水平相关的疾病。
• Compounds, Compositions and Methods of Using Same for Modulating Uric Acid Levels
  申请人：GUNIC Esmir

  公开号：US20130040907A1

  公开（公告）日：2013-02-14

  Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

  本文描述了在调节血尿酸水平方面有用的化合物，包含它们的配方以及制备和使用它们的方法。在某些实施例中，所述化合物用于治疗或预防与尿酸异常水平相关的疾病。
• Compounds, compositions and methods of using same for modulating uric acid levels
  申请人：Ardea Biosciences, Inc.

  公开号：US20160221969A1

  公开（公告）日：2016-08-04

  Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

  本文描述的是在调节血液尿酸水平方面有用的化合物，包含它们的配方以及制备和使用它们的方法。在某些实施例中，本文所描述的化合物可用于治疗或预防与异常尿酸水平相关的疾病。
• COMPOUNDS, COMPOSITIONS AND METHODS OF USING SAME FOR MODULATING URIC ACID LEVELS
  申请人：ARDEA BIOSCIENCES, INC.

  公开号：US20140128338A1

  公开（公告）日：2014-05-08

  Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

  本文描述了用于调节血尿酸水平的化合物，包含它们的制剂和制备和使用它们的方法。在某些实施例中，所述化合物用于治疗或预防与异常尿酸水平相关的疾病。
• MANUFACTURE OF 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID
  申请人：ARDEA BIOSCIENCES, INC.

  公开号：US20160214947A1

  公开（公告）日：2016-07-28

  Described herein are certain processes for the synthesis of compounds of Formula (I):

  本文描述了一些合成式(I)化合物的过程：